06-873 | Anti-Casein Kinase 2 Antibody

06-873
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-873
      Replaces04-1129
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Casein Kinase 2 Antibody
      References
      Product Information
      FormatPurified
      Control
      • Positive Control Included: 3T3 Cell Lysate (12-305)
      PresentationProtein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
      Applications
      ApplicationAnti-Casein Kinase 2 Antibody is an antibody against Casein Kinase 2 for use in WB.
      Key Applications
      • Western Blotting
      Application NotesNot recommended for IP.
      Biological Information
      Immunogenpeptide (C-SRARVYTDVNTHRPRE) corresponding to amino acids 7-22 of human Casein Kinase 2
      HostRabbit
      SpecificityRecognizes Casein Kinase 2.
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryCasein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene.
      Gene Symbol
      • CSNK2A1
      • CKII
      • CK2A1
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P68400 # Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. Participates in Wnt signaling. CK2 phosphorylates 'Ser-392' of p53/TP53 following UV irradiation.
      SIZE: 391 amino acids; 45144 Da
      SUBUNIT: Tetramer composed of an alpha chain, an alpha' and two beta chains. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with RNPS1.
      SIMILARITY: SwissProt: P68400 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily. & Contains 1 protein kinase domain.
      Molecular Weight44 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from mouse 3T3/A31 fibroblasts or A431 cell lysates
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Casein Kinase 2 2484177
      Anti-Casein Kinase 2 (rabbit polyclonal IgG) 2869704
      Anti-Casein Kinase 2 - 18836 18836
      Anti-Casein Kinase 2 - 24971 24971
      Anti-Casein Kinase 2 -2752527 2752527
      Anti-Casein Kinase 2 -2791193 2791193

      References

      Reference overviewPub Med ID
      Calcium dependence of polycystin-2 channel activity is modulated by phosphorylation at Ser812.
      Cai, Y; Anyatonwu, G; Okuhara, D; Lee, KB; Yu, Z; Onoe, T; Mei, CL; Qian, Q; Geng, L; Wiztgall, R; Ehrlich, BE; Somlo, S
      The Journal of biological chemistry  279  19987-95  2004

      Show Abstract
      14742446 14742446
      Proteomic analysis of proteins in PC12 cells before and after treatment with nerve growth factor: increased levels of a 43-kDa chromogranin B-derived fragment during neuronal differentiation.
      C M Huang,H A Shui,Y T Wu,P W Chu,K G Lin,L S Kao,S T Chen
      Brain research. Molecular brain research  92  2001

      Show Abstract
      11483256 11483256
      Casein kinase 2 associates with and phosphorylates dishevelled.
      Willert, K, et al.
      EMBO J., 16: 3089-96 (1997)  1997

      Show Abstract
      9214626 9214626
      Protein kinase CK2 ("casein kinase-2") and its implication in cell division and proliferation.
      Pinna, L A and Meggio, F
      Prog Cell Cycle Res, 3: 77-97 (1997)  1997

      Show Abstract
      9552408 9552408

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies