06-480 | Anti-Cathepsin B Antibody

06-480
400 µg  2 vials of 200 μg
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, RIHC, WBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-480
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Cathepsin B Antibody
      References
      Product Information
      FormatPurified
      Control
      • A431 Cell Lysate
      PresentationProtein A Purified immunoglobulin. 0.1 M Tris-Glycine, 0.15 M NaCl, 0.05% sodium azide, pH 7.4.
      Applications
      ApplicationAnti-Cathepsin B Antibody detects level of Cathepsin B & has been published & validated for use in IH & WB.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Biological Information
      ImmunogenRecombinant rat procathepsin B 1
      HostRabbit
      SpecificityRecognizes procathepsin B and mature cathepsin B.
      IsotypeIgG
      Species Reactivity
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene.
      Gene Symbol
      • CTSB
      • CPSB
      • APPS
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P07858 # Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
      SIZE: 339 amino acids; 37822 Da
      SUBUNIT: Dimer of a heavy chain and a light chain cross-linked by a disulfide bond.
      SUBCELLULAR LOCATION: Lysosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
      SIMILARITY: SwissProt: P07858 ## Belongs to the peptidase C1 family.
      Molecular Weightprocathepsin B (40 kDa) and mature cathepsin B (25 kDa, 26 kDa and 30 kDa)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on rat kidney microsomal preparation (Catalog #12-146)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size400 µg
      Material Package2 vials of 200 μg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Cathepsin B (rabbit polyclonal IgG) - 1946445 1946445
      Anti-Cathepsin B (rabbit polyclonal IgG) - 1993906 1993906
      Anti-Cathepsin B (rabbit polyclonal IgG) - 2197503 2197503
      Anti-Cathepsin B (rabbit polyclonal IgG) - 2203104 2203104
      Anti-Cathepsin B (rabbit polyclonal IgG) - 2343121 2343121
      Anti-Cathepsin B (rabbit polyclonal IgG) - DAM1437120 DAM1437120
      Anti-Cathepsin B - 0605029340 0605029340
      Anti-Cathepsin B - 1350293 1350293
      Anti-Cathepsin B - 14927 14927
      Anti-Cathepsin B - 23694 23694

      References

      Reference overviewApplicationPub Med ID
      Angiogenin secretion from hepatoma cells activates hepatic stellate cells to amplify a self-sustained cycle promoting liver cancer.
      Bárcena, C; Stefanovic, M; Tutusaus, A; Martinez-Nieto, GA; Martinez, L; García-Ruiz, C; de Mingo, A; Caballeria, J; Fernandez-Checa, JC; Marí, M; Morales, A
      Scientific reports  5  7916  2015

      Show Abstract
      25604905 25604905
      Increased immunoreactivity of cathepsins in the rat esophagus under chronic acid reflux esophagitis.
      Suyama, M; Koike, M; Asaoka, D; Mori, H; Oguro, M; Ueno, T; Nagahara, A; Watanabe, S; Uchiyama, Y
      The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society  62  645-60  2014

      Show Abstract
      24943348 24943348
      Streptozotocin-induced diabetes mellitus affects lysosomal enzymes in rat liver.
      Peres, GB; Juliano, MA; Aguiar, JA; Michelacci, YM
      Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]  47  452-60  2014

      Show Abstract
      Immunohistochemistry24820066 24820066
      Increased intracranial pressure after diffuse traumatic brain injury exacerbates neuronal somatic membrane poration but not axonal injury: evidence for primary intracranial pressure-induced neuronal perturbation.
      Lafrenaye, AD; McGinn, MJ; Povlishock, JT
      Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism  32  1919-32  2012

      Show Abstract
      22781336 22781336
      Cathepsin B overexpression due to acid sphingomyelinase ablation promotes liver fibrosis in Niemann-Pick disease.
      Moles, A; Tarrats, N; Fernández-Checa, JC; Marí, M
      The Journal of biological chemistry  287  1178-88  2012

      Show Abstract
      22102288 22102288
      Downregulation of doxorubicin-induced myocardial apoptosis accompanies postnatal heart maturation.
      Shi, J; Zhang, L; Zhang, YW; Surma, M; Mark Payne, R; Wei, L
      American journal of physiology. Heart and circulatory physiology  302  H1603-13  2012

      Show Abstract
      22328080 22328080
      Cathepsin B, cathepsin L, and cystatin C in the porcine uterus and placenta: potential roles in endometrial/placental remodeling and in fluid-phase transport of proteins secreted by uterine epithelia across placental areolae.
      Song G, Bailey DW, Dunlap KA, Burghardt RC, Spencer TE, Bazer FW, Johnson GA
      Biol Reprod  82  854-64 Epub 2010 Jan 27  2010

      Show Abstract
      20107207 20107207
      Effects of long-term progesterone on developmental and functional aspects of porcine uterine epithelia and vasculature: progesterone alone does not support development of uterine glands comparable to that of pregnancy.
      Bailey, DW; Dunlap, KA; Frank, JW; Erikson, DW; White, BG; Bazer, FW; Burghardt, RC; Johnson, GA
      Reproduction (Cambridge, England)  140  583-94  2010

      Show Abstract
      20634388 20634388
      Vesicular egress of non-enveloped lytic parvoviruses depends on gelsolin functioning.
      Bär, S; Daeffler, L; Rommelaere, J; Nüesch, JP
      PLoS pathogens  4  e1000126  2008

      Show Abstract Full Text Article
      18704167 18704167
      Simultaneous human papilloma virus type 16 E7 and cdk inhibitor p21 expression induces apoptosis and cathepsin B activation.
      Kaznelson, DW; Bruun, S; Monrad, A; Gjerløv, S; Birk, J; Röpke, C; Norrild, B
      Virology  320  301-12  2004

      Show Abstract
      15016552 15016552