07-981 | Anti-Cbx7 Antibody

07-981
100 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Click To Print This Page

      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWB, IPRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-981
      DescriptionAnti-Cbx7 Antibody
      Alternate Names
      • chromobox homolog 7
      • chromobox protein homolog 7
      Background InformationChromobox protein homologue 7 (Cbx7) is a member of the mammalian chromobox family of proteins. As a component of the Polycomb repressive complex 1 (PRC1), Cbx7, is involved in the maintenance and prolongation of cultured epithelial cell lifespan, and has been shown to function independently of BMI-1 in the repression of INK4a/ARF, a known tumor suppressor locus. Cbx7 is also able to regulate cellular lifespan through maintaining CDKN2A repression. Studies have shown Cbx7 to be up-regulated in follicular lymphoma, suggesting potential as a human oncogene.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Mouse embryonic stem cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-Cbx7 Antibody is a Rabbit Polyclonal Antibody for detection of Chromobox protein homolog 7 (Cbx7) also known as hromobox protein homolog 7 & has been validated in WB & IP.
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      Application NotesWestern Blot (Snap i.d.®) Analysis: 2 µg/mL from a representative lot detected Cbx7 on 10 µg of human and mouse embryonic stem cell lysates.

      Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in IP.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the C-terminus of mouse Cbx7.
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes Cbx7 at the C-terminus.
      Species Reactivity
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CBX7
      • Cbx7
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Involved in maintaining the transcriptionally repressive state of genes. Modifies chromatin, rendering it heritably changed in its expressibility (By similarity). Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.

      SUBUNIT STRUCTURE: Component of the chromatin-associated polycomb complex (PcG). Interacts with RING2 (By similarity). Interacts with RING1, but not with BMI1, EED or EZH2.

      SUBCELLULAR LOCATION: Nucleus

      DEVELOPMENTAL STAGE: In embryonic fibroblast cultured in vitro, expression gradually decreases with passage number and totally disappears in senescent cells.

      SEQUENCE SIMILARITIES: Contains 1 chromo domain.
      Molecular Weight~21 kDa observed. A non-specific band at ~ 44 kDa and may be observed in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in mouse embryonic stem cell lysate.

      Western Blot Analysis: 0.25 µg/mL of this antibody detected Cbx7 on 10 µg of mouse embryonic stem cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Chromobox protein homolog 7 (Cbx7) 2479822
      Anti-Chromobox protein homolog 7 (Cbx7) - 2399473 2399473
      Anti-Chromobox protein homolog 7 (Cbx7) - 2006940 2006940
      Anti-Chromobox protein homolog 7 (Cbx7) - 2376684 2376684
      Anti-Chromobox protein homolog 7 (Cbx7) - NRG1798850 NRG1798850
      Anti-Chromobox protein homolog 7 (Cbx7) -2759703 2759703
      Anti-Chromobox protein homolog 7 (Cbx7) -2855895 2855895
      Anti-Chromobox protein homolog 7 (Cbx7) Polyclonal Antibody 2918032
      Anti-Chromobox protein homolog 7 (Cbx7) Polyclonal Antibody 2989489
      Anti-Chromobox protein homolog 7 (Cbx7) Polyclonal Antibody 2864879

      References

      Reference overviewApplicationSpeciesPub Med ID
      Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes.
      He, J; Shen, L; Wan, M; Taranova, O; Wu, H; Zhang, Y
      Nature cell biology  15  373-84  2013

      Show Abstract
      ImmunocytochemistryMouse23502314 23502314

      Related Products & Applications

      Related Products

      Catalogue Number Description  
      06-1414 Anti-phospho Cbx7 (Thr118) Antibody Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies