07-981 Anti-Cbx7 Antibody

100 µg  
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      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWB, IPRbAffinity PurifiedPolyclonal Antibody
      Catalogue Number07-981
      DescriptionAnti-Cbx7 Antibody
      Alternate Names
      • chromobox homolog 7
      • chromobox protein homolog 7
      Background InformationChromobox protein homologue 7 (Cbx7) is a member of the mammalian chromobox family of proteins. As a component of the Polycomb repressive complex 1 (PRC1), Cbx7, is involved in the maintenance and prolongation of cultured epithelial cell lifespan, and has been shown to function independently of BMI-1 in the repression of INK4a/ARF, a known tumor suppressor locus. Cbx7 is also able to regulate cellular lifespan through maintaining CDKN2A repression. Studies have shown Cbx7 to be up-regulated in follicular lymphoma, suggesting potential as a human oncogene.
      Product Information
      FormatAffinity Purified
      • Mouse embryonic stem cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationAnti-Cbx7 Antibody is a Rabbit Polyclonal Antibody for detection of Chromobox protein homolog 7 (Cbx7) also known as hromobox protein homolog 7 & has been validated in WB & IP.
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      Application NotesWestern Blot (Snap i.d.®) Analysis: 2 µg/mL from a representative lot detected Cbx7 on 10 µg of human and mouse embryonic stem cell lysates.

      Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in IP.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the C-terminus of mouse Cbx7.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis antibody recognizes Cbx7 at the C-terminus.
      Species Reactivity
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CBX7
      • Cbx7
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Involved in maintaining the transcriptionally repressive state of genes. Modifies chromatin, rendering it heritably changed in its expressibility (By similarity). Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.

      SUBUNIT STRUCTURE: Component of the chromatin-associated polycomb complex (PcG). Interacts with RING2 (By similarity). Interacts with RING1, but not with BMI1, EED or EZH2.


      DEVELOPMENTAL STAGE: In embryonic fibroblast cultured in vitro, expression gradually decreases with passage number and totally disappears in senescent cells.

      SEQUENCE SIMILARITIES: Contains 1 chromo domain.
      Molecular Weight~21 kDa observed. A non-specific band at ~ 44 kDa and may be observed in some lysates.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in mouse embryonic stem cell lysate.

      Western Blot Analysis: 0.25 µg/mL of this antibody detected Cbx7 on 10 µg of mouse embryonic stem cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Chromobox protein homolog 7 (Cbx7)2479822
      Anti-Chromobox protein homolog 7 (Cbx7) - 23994732399473
      Anti-Chromobox protein homolog 7 (Cbx7) - 20069402006940
      Anti-Chromobox protein homolog 7 (Cbx7) - 23766842376684
      Anti-Chromobox protein homolog 7 (Cbx7) - NRG1798850NRG1798850
      Anti-Chromobox protein homolog 7 (Cbx7) -27597032759703
      Anti-Chromobox protein homolog 7 (Cbx7) -28558952855895
      Anti-Chromobox protein homolog 7 (Cbx7) Polyclonal Antibody2864879
      Anti-Chromobox protein homolog 7 (Cbx7) Polyclonal Antibody2918032
      Anti-Chromobox protein homolog 7 (Cbx7) Polyclonal Antibody2989489


      Reference overviewApplicationSpeciesPub Med ID
      Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes.
      He, J; Shen, L; Wan, M; Taranova, O; Wu, H; Zhang, Y
      Nature cell biology  15  373-84  2013

      Show Abstract
      ImmunocytochemistryMouse23502314 23502314

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      Life Science Research > Antibodies and Assays > Primary Antibodies