05-550 | Anti-Cdc6 Antibody, clone DCS-180

05-550
100 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Click To Print This Page

      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MIP, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-550
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Cdc6 Antibody, clone DCS-180
      References
      Product Information
      FormatPurified
      Presentation10mM PBS, pH 7.4 and 0.05% sodium azide
      Applications
      ApplicationDetect Cdc6 with Anti-Cdc6 Antibody, clone DCS-180 (Mouse Monoclonal Antibody), that has been shown to work in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenRecombinant, full-length human cdc6
      Cloneclone DCS-180
      HostMouse
      Specificitycdc6
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.
      Gene Symbol
      • CDC6
      • HsCDC18
      • cdc6
      • HsCDC6
      • p62
      • CDC18L
      Purification MethodProtein G Chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q99741 # Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
      SIZE: 560 amino acids; 62720 Da
      SUBUNIT: Interacts with PCNA, ORC1L and cyclin-CDK.
      SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=The protein is nuclear in G1 and cytoplasmic in S-phase cells.
      SIMILARITY: SwissProt: Q99741 ## Belongs to the CDC6/cdc18 family.
      Molecular Weight62kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on HeLa nuclear extract or 3T3 nuclear extract
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-cdc6, clone DCS-180 (mouse monoclonal IgG1) - 2121733 2121733
      Anti-cdc6, clone DCS-180 (mouse monoclonal IgG1) - 2349461 2349461
      Anti-cdc6, clone DCS-180 (mouse monoclonal IgG1) - 229714 229714
      Anti-cdc6, clone DCS-180 (mouse monoclonal IgG1) - DAM1828788 DAM1828788
      Anti-cdc6, clone DCS-180 - 19286 19286
      Anti-cdc6, clone DCS-180 - 1984652 1984652
      Anti-cdc6, clone DCS-180 - 1988271 1988271
      Anti-cdc6, clone DCS-180 - 23769 23769
      Anti-cdc6, clone DCS-180 - 2492107 2492107
      Anti-cdc6, clone DCS-180 - 26096 26096

      References

      Reference overviewPub Med ID
      Forced Expression of ZNF143 Restrains Cancer Cell Growth.
      Izumi, H; Yasuniwa, Y; Akiyama, M; Yamaguchi, T; Kuma, A; Kitamura, N; Kohno, K
      Cancers  3  3909-20  2011

      Show Abstract
      24213117 24213117
      Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
      Petersen, B O, et al.
      EMBO J., 18: 396-410 (1999)  1999

      Show Abstract
      9889196 9889196
      Putting it all together: building a prereplicative complex.
      Newlon, C S
      Cell, 91: 717-20 (1997)  1997

      9413980 9413980
      Initiation of DNA replication in eukaryotic cells.
      Dutta, A and Bell, S P
      Annu. Rev. Cell Dev. Biol., 13: 293-332 (1997)  1997

      Show Abstract
      9442876 9442876

      Related Products & Applications

      Included Positive Control

      Catalogue Number Description  
      12-309 HeLa Nuclear Extract Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies