CBL198 | Anti-Cytokeratin 19 Antibody, clone BA 17

CBL198
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICC, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberCBL198
      ReplacesCBL178
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Cytokeratin 19 Antibody, clone BA 17
      References
      Product Information
      FormatPurified
      PresentationThe monoclonal is presented at a concentration of 0.1mg/1ml in phosphate buffered saline containing 10mM sodium azide and 1% bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application.
      Applications
      ApplicationDetect Cytokeratin 19 using this Anti-Cytokeratin 19 Antibody, clone BA 17 validated for use in WB, IC, IH(P).
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Immunohistochemistry (Paraffin)
      Application NotesImmunocytochemistry

      Western blotting

      Suitable for staining frozen and paraffin wax embedded tissue sections after proteolytic enzyme digestion

      Cytokeratin 19 positive detection distinguishes malignant from benign breast tumours

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenHuman reduction mammoplasty organoids
      CloneBA 17
      HostMouse
      SpecificityThe antibody is specific to human cytokeratin 19 and is reactive with cells of epithelial origin. Cytokeratin 19 is the smallest human cytokeratin (40 kDa) and is found in many simple and invariably in some non-keratinising stratified squamous epithelia. All adenocarcinomas tested have been positive for cytokeratin 19.

      FUSION PARTNER: Px63 Ag 8.653 myeloma cell line
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21.
      Gene Symbol
      • KRT19
      • Keratin-19
      • K19
      • CK19
      • MGC15366
      • K1CS
      • Cytokeratin-19
      • CK-19
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P08727 # Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
      SIZE: 400 amino acids; 44092 Da
      SUBUNIT: Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD. Interacts with HCV core protein.
      TISSUE SPECIFICITY: Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.DEVELOPMENTAL STAGE: Present in hair follicles at all stages of development.
      DOMAIN: SwissProt: P08727 This keratin differs from all other IF proteins in lacking the C-terminal tail domain.
      SIMILARITY: Belongs to the intermediate filament family.
      MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsFor use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-HUMAN CYTOKERATIN 19 MONOCLONAL ANTIBODY - 2421557 2421557
      MOUSE ANTI-HUMAN CYTOKERATIN 19 MONOCLONAL ANTIBODY - 2533143 2533143
      MOUSE ANTI-HUMAN CYTOKERATIN 19 MONOCLONAL ANTIBODY -2806939 2806939

      References

      Reference overviewPub Med ID
      Patterns of expression of keratin 19 as detected with monoclonal antibodies in human breast tissues and tumours.
      Bartek, J, et al.
      Int. J. Cancer, 36: 299-306 (1985)  1985

      2411673 2411673

      Data Sheet

      Title
      Anti-Cytokeratin 19, clone BA 17 - Data Sheet

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      Product Families

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies