06-744 | Anti-DR4/TRAIL-R1 Antibody

06-744
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-744
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-DR4/TRAIL-R1 Antibody
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
      Applications
      ApplicationDetect DR4/TRAIL-R1 using this Anti-DR4/TRAIL-R1 Antibody validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      Immunogenpeptide (C-RPAREASPRLRVHK) corresponding to amino acids 77-90 of human DR4/TRAIL-R1
      HostRabbit
      SpecificityDR4/TRAIL-R1
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
      Gene Symbol
      • TNFRSF10A
      • TRAILR1
      • APO2
      • CD261
      • DR4
      • TRAIL-R1
      • TRAILR-1
      • MGC9365
      • Apo2
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O00220 # Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B.
      SIZE: 468 amino acids; 50061 Da
      SUBUNIT: Can interact with TRADD and RIP.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells.
      SIMILARITY: SwissProt: O00220 ## Contains 1 death domain. & Contains 3 TNFR-Cys repeats.
      Molecular Weight57kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from Jurkat cells, A431, HeLa, HFF, Raji, 3T3, CTLL, L-6 or PC-12 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-DR4/TRAIL-R1 2472916
      Anti-DR4/TRAIL-R1 (rabbit polyclonal IgG) 2977290
      Anti-DR4/TRAIL-R1 - 17081 17081
      Anti-DR4/TRAIL-R1 - 27520 27520

      References

      Reference overviewPub Med ID
      Akt-phosphorylated mitogen-activated kinase-activating death domain protein (MADD) inhibits TRAIL-induced apoptosis by blocking Fas-associated death domain (FADD) association with death receptor 4.
      Li, P; Jayarama, S; Ganesh, L; Mordi, D; Carr, R; Kanteti, P; Hay, N; Prabhakar, BS
      The Journal of biological chemistry  285  22713-22  2010

      Show Abstract Full Text Article
      20484047 20484047
      Death receptor pathways mediate targeted and non-targeted effects of ionizing radiations in breast cancer cells.
      Luce, A; Courtin, A; Levalois, C; Altmeyer-Morel, S; Romeo, PH; Chevillard, S; Lebeau, J
      Carcinogenesis  30  432-9  2009

      Show Abstract Full Text Article
      19126655 19126655
      The receptor for the cytotoxic ligand TRAIL.
      Pan, G, et al.
      Science, 276: 111-3 (1997)  1997

      Show Abstract
      9082980 9082980

      Brochure

      Title
      Comprehensive solutions for studying cell health - Life, death, and everything in between.

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies