04-721-25UL | Anti-Dicer1 Antibody, clone 5D12.2 (mouse monoclonal)

New04-721-25UL
25 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-721-25UL
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Dicer1 Antibody, clone 5D12.2 (mouse monoclonal)
      Alternate Names
      • DCR1
      • Dicer
      • HERNA
      • KIAA0928
      Background InformationRNA interference (RNAi) is mechanism for post-transcriptional gene silencing that leads to the loss of the activity of the gene. RNAi is activated when long dsRNAs are cleaved by the enzyme Dicer1 (RNase III family of dsRNA-specific endonucleases) into 21-23 nucleotide siRNA (small interfering RNA). These siRNAs bind proteins to form the RISC (RNA-induced silencing complex) which is activated when the double stranded siRNAs are unzipped to single stranded siRNAs. Activated RISC recognizes and binds complementary sequences in mRNA. The mRNA is cleaved and the overall effect is an inhibition of the protein expression and a loss of the gene activity. Dicer1 along with the Argonaute family of proteins (Ago1 and Ago2) share the same domain PIWI and PAZ domain that provide endonuclease activity to RNA-induced silencing complexes (RISC).
      References
      Product Information
      FormatPurified
      Presentation0.02M phosphate buffer, pH 7.6, 0.25M NaCl, and 0.1% sodium azide.
      Applications
      ApplicationAnti-Dicer1 Antibody, clone 5D12.2 is a Mouse Monoclonal Antibody for detection of Dicer1 also known as DCR1, Dicer, HERNA, KIAA0928 & has been validated in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern blot
      Biological Information
      ImmunogenKLH conjugated synthetic peptide corresponding to amino acids 378-385 of human Dicer1
      Clone5D12.2
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityHuman Dicer1
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • DICER1
      • DICER
      • HERNA
      Purification MethodProtein G Chromatography
      UniProt Number
      Molecular Weight220 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by western blot on lysates from HeLa nuclear extracts.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
      Packaging Information
      Material Size25 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation