CBL180F | Anti-E-Selectin Antibody, clone 1.2B6, FITC conjugated

CBL180F
100 assays  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, PoFCMFITCMonoclonal Antibody
      Description
      Catalogue NumberCBL180F
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-E-Selectin Antibody, clone 1.2B6, FITC conjugated
      Alternate Names
      • ELAM-1
      • CD62E
      References
      Product Information
      FormatFITC
      PresentationThe conjugate is supplied as a 100 test vial in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. For flow cytometry we recommend using 10μL of conjugate per test.
      Applications
      ApplicationDetect E-Selectin using this Anti-E-Selectin Antibody, clone 1.2B6, FITC conjugated validated for use in FC.
      Key Applications
      • Flow Cytometry
      Application NotesStudies in a wide range of cell interactions in the vasculature together with diagnostic implications

      This antibody works in ELISA, immunohistology and also inhibits cellular adhesion

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenTNF-activated human umbilical vein endothelial cells
      Clone1.2B6
      HostMouse
      SpecificityThe antibody is specific to the human antigen E-selectin (ELAM-1, 115 kDa) that is expressed on activated endothelial cells. The ligand is expressed on neutrophils and may function as an early part in neutrophil binding to the endothelium.
      KNOWN SPECIES CROSS REACTIVITY: Recognizes porcine E-selectin
      IsotypeIgG1
      Species Reactivity
      • Human
      • Pig
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe endothelial leukocyte adhesion molecule-1 is expressed by cytokine-stimulated endothelial cells. It is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. This gene is present in single copy in the human genome and contains 14 exons spanning about 13 kb of DNA. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis.
      Gene Symbol
      • SELE
      • LECAM2
      • ESEL
      • ELAM
      • ELAM-1
      • CD62E
      • ELAM1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P16581 # Expressed on cytokine induced endothelial cells and mediates their binding to leukocytes. The ligand recognized by ELAM-1 is sialyl-lewis X (alpha(1->3)fucosylated derivatives of polylactosamine that are found at the nonreducing termini of glycolipids).
      SIZE: 610 amino acids; 66655 Da
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      SIMILARITY: SwissProt: P16581 ## Belongs to the selectin/LECAM family. & Contains 1 C-type lectin domain. & Contains 1 EGF-like domain. & Contains 6 Sushi (CCP/SCR) domains.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at +4°C protected from light. DO NOT FREEZE. For long term use and storage aliquot conjugate into small volumes and store at +4°C.
      Packaging Information
      Material Size100 assays
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overviewPub Med ID
      Identification of uPAR-positive chemoresistant cells in small cell lung cancer.
      Gutova, M; Najbauer, J; Gevorgyan, A; Metz, MZ; Weng, Y; Shih, CC; Aboody, KS
      PloS one  2  e243  2007

      Show Abstract
      17327908 17327908
      Selectins.
      Bevilacqua, M P and Nelson, R M
      J. Clin. Invest., 91: 379-87 (1993)  1993

      7679406 7679406
      Endothelial leucocyte adhesion molecule-1 (ELAM-1) expression in cutaneous inflammation.
      Groves, R W, et al.
      Br. J. Dermatol., 124: 117-23 (1991)  1991

      Show Abstract
      1706195 1706195

      Data Sheet

      Title
      Anti-E-selectin, Clone 1.2B6, FITC Conjugated - Data Sheet

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      Alternative Format

      Catalogue Number Description  
      CBL180 Anti-CD62E [ELAM-1] Antibody, clone 1.2B6 Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies