06-1052 | Anti-Emerin Antibody

06-1052
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbUnpurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1052
      DescriptionAnti-Emerin Antibody
      Alternate Names
      • Emery-Dreifuss muscular dystrophy
      • LEM domain containing 5
      Background InformationEmerin is a LEM domain-containing integral membrane protein of the nuclear membrane in vertebrates. Emerin is known to interact with nuclear lamins, barrier-to-autointegration factor (BAF), nesprin-1 alpha, and a transcription repressor. Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Mutations to emerin result in Dreifuss-Emery muscular dystrophy, an X-linked inherited degenerative myopathy.
      References
      Product Information
      FormatUnpurified
      Control
      • A431 cell lysate
      PresentationRabbit polyclonal serum with 0.05% sodium azide.
      Applications
      ApplicationAnti-Emerin Antibody is a Rabbit Polyclonal Antibody for detection of Emerin also known as Emery-Dreifuss muscular dystrophy, LEM domain containing 5 & has been validated in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenRecombinant protein corresponding to residues surrounding the N-terminus region of Emerin.
      EpitopeN-terminus
      HostRabbit
      SpecificityThis antibody recognizes Emerin at and around the N-terminus.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryEmerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene.
      Gene Symbol
      • EDMD
      • LEMD5
      • OTTHUMP00000031938
      • OTTHUMP00000061687
      • STA
      • emerin
      Purification MethodUnpurified
      UniProt Number
      UniProt SummarySUBUNIT STRUCTURE: Interacts with lamins A and C, BANF1, GMCL, BCLAF1 and YTHDC1/YT521. Interacts with TMEM43; the interaction retains emerin in the nuclear inner membrane By similarity.
      SUBCELLULAR LOCATION: Nucleus inner membrane; Single-pass membrane protein; Nucleoplasmic side. Note: Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites.
      TISSUE SPECIFICITY: Skeletal muscle, heart, colon, testis, ovary and pancreas.
      PTM: Found in four different phosphorylated forms, three of which appear to be associated with the cell cycle.
      INVOLVEMENT IN DISEASE: Defects in EMD are a cause of X-linked Emery-Dreifuss muscular dystrophy (X-EDMD) [MIM:310300]. X-EDMD is an X-linked disorder characterized by early contractures, muscle wasting and weakness and cardiomyopathy.
      MISCELLANEOUS: Binding to BCLAF1 is specifically and selectively disrupted by the disease-associated Phe-54 missense mutation.
      SEQUENCE SIMILARITIES: Contains 1 LEM domain.
      Molecular Weight~35 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in A431 cell lysate.
      Western Blot Analysis: A 1:1,000 dilution of this antibody detected Emerin in 10 µg of A431 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Emerin - NRG1633604 NRG1633604

      References

      Reference overviewPub Med ID
      Dopaminergic-like neurons derived from oral mucosa stem cells by developmental cues improve symptoms in the hemi-parkinsonian rat model.
      Ganz, J; Arie, I; Buch, S; Zur, TB; Barhum, Y; Pour, S; Araidy, S; Pitaru, S; Offen, D
      PloS one  9  e100445  2014

      Show Abstract
      24945922 24945922
      Human telomeres are tethered to the nuclear envelope during postmitotic nuclear assembly.
      Crabbe, L; Cesare, AJ; Kasuboski, JM; Fitzpatrick, JA; Karlseder, J
      Cell reports  2  1521-9  2012

      Show Abstract
      23260663 23260663

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies