05-1424 | Anti-Endoglin Antibody, clone P3D1

100 µg  
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      Replacement Information
      Replacement Information05-1424 is a recommended replacement for MAB2152

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IHC, ICC, IP, FC, ELISAMPurifiedMonoclonal Antibody
      Catalogue Number05-1424
      DescriptionAnti-Endoglin Antibody, clone P3D1
      Alternate Names
      • CD105
      • Ancillary TGF-beta Receptor
      Background InformationEndoglin is a homodimeric integral membrane glycoprotein comprised of 95 kDa subunit. Endoglin is a component of the TGF-B receptor system that functions as an ancillary receptor influencing binding of the Transforming Growth Factor beta (TGF-β) family ligands to signaling receptors. Endoglin binds TGF-B1 and TGF-B3 with high affinity but does not bind TGF-B2. Endoglin is expressed by vascular endothelial cells and syncytiotrophoblasts of placenta and is weakly expressed by stromalfibroblasts. It is also expressed by U937 cells and activated macrophages. Endoglin expression is up regulated on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation.
      Product Information
      • Jurkat cell lysate
      PresentationPurified mouse monoclonal IgG2a in 0.02M phosphate buffer, 0.25M sodium chloride, 0.1% sodium azide, pH 7.6
      ApplicationAnti-Endoglin Antibody, clone P3D1 is an antibody against Endoglin for use in WB, IH, IC, IP, FC, ELISA.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunocytochemistry
      • Immunoprecipitation
      • Flow Cytometry
      • ELISA
      Application NotesImmunohistochemistry: For use on acetone or paraformaldehyde fixed tissue.

      ELISA: A previous lot of this antibody was used in ELISA.

      Immunoprecipitation: A previous lot of this antibody was used in IP.

      Immunocytochemistry: A previous lot of this antibody was used in IC.

      Flow Cytometry: A previous lot of this antibody was used in FC.

      Optimal working dilutions must be determined by the end user.

      Biological Information
      ImmunogenHuman resting umbilical vein endothelial cells.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityReacts with human endoglin.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteHuman and mouse. Expected to react with rat based on sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryEndoglin is a homodimeric transmembrane glycoprotein highly expressed by endothelial cells. It is a component of the transforming growth factor beta receptor complex as it binds TGFB1 and TGFB3 with high affinity. Mutations in the endoglin gene produce hereditary hemorrhagic telangiectasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
      Gene Symbol
      • ENG
      • ORW
      • CD105
      • HHT1
      • END
      • FLJ41744
      • ORW1
      • endoglin
      Purification MethodPurified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P17813 # Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.
      SIZE: 658 amino acids; 70578 Da
      SUBUNIT: Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGF-beta receptors I and/or II. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Endoglin is restricted to endothelial cells in all tissues except bone marrow.
      DISEASE: SwissProt: P17813 # Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300, 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity.
      Molecular Weight~71 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by Western Blot on Jurkat lysates.

      Western Blot Analysis: 1:500 dilution of this lot detected ENDOGLIN on 10 μg of Jurkat lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable at 2-8°C for up to 1 year from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Endoglin, clone P3D1 3079112
      Anti-Endoglin, clone P3D1 - 2043922 2043922
      Anti-Endoglin, clone P3D1 - 2090140 2090140
      Anti-Endoglin, clone P3D1 - 2168271 2168271
      Anti-Endoglin, clone P3D1 - 2225200 2225200
      Anti-Endoglin, clone P3D1 - 2328383 2328383
      Anti-Endoglin, clone P3D1 - 2491200 2491200
      Anti-Endoglin, clone P3D1 - DAM1621700 DAM1621700
      Anti-Endoglin, clone P3D1 - JBC1771127 JBC1771127
      Anti-Endoglin, clone P3D1 - NG1576283 NG1576283


      Reference overviewApplicationSpeciesPub Med ID
      Conditional overexpression of TGFβ1 promotes pulmonary inflammation, apoptosis and mortality via TGFβR2 in the developing mouse lung.
      Sureshbabu, A; Syed, MA; Boddupalli, CS; Dhodapkar, MV; Homer, RJ; Minoo, P; Bhandari, V
      Respiratory research  16  4  2015

      Show Abstract
      Immunohistochemistry25591994 25591994
      Multipotent neural crest stem cell-like cells from rat vibrissa dermal papilla induce neuronal differentiation of PC12 cells.
      Li, M; Liu, JY; Wang, S; Xu, H; Cui, L; Lv, S; Xu, J; Liu, S; Chi, G; Li, Y
      BioMed research international  2014  186239  2014

      Show Abstract
      ImmunocytochemistryRat25045659 25045659
      Snail1 controls TGF-β responsiveness and differentiation of mesenchymal stem cells.
      Batlle, R, et al.
      Oncogene, (2012)  2012

      Show Abstract
      22869142 22869142

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      Product Families


      Life Science Research > Antibodies and Assays > Primary Antibodies