05-149 | Anti-FGFR1 Antibody, clone 19B2

05-149
250 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RIP, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-149
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-FGFR1 Antibody, clone 19B2
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl containing 0.05% sodium azide
      Applications
      ApplicationAnti-FGFR1 Antibody, clone 19B2 detects level of FGFR1 & has been published & validated for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenE. coli fusion protein corresponding to amino acids 23-325 of human FGF receptor beta (Flg)
      Cloneclone 19B2
      HostMouse
      Specificityextra cellular domain for both (alpha and beta) human FGF receptor
      IsotypeIgG1
      Species Reactivity
      • Human
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
      Gene Symbol
      • FGFR1
      • CEK
      • bFGF-R
      • N-SAM
      • H5
      • FLT2
      • BFGFR
      • FGFR-1
      • c-fgr
      • FLG
      • H3
      • H2
      • KAL2
      • HBGFR
      • CD331
      • H4
      • FGFBR
      Purification MethodProtein G Chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P11362 # Receptor for basic fibroblast growth factor. A shorter form of the receptor could be a receptor for FGF1 (aFGF).
      SIZE: 822 amino acids; 91868 Da
      SUBUNIT: Interacts with SHB. Interacts with KLB (By similarity).
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      PTM: Binding of FGF1 and heparin promotes autophosphorylation on tyrosine residues and activation of the receptor.
      DISEASE: SwissProt: P11362 # Defects in FGFR1 are a cause of Pfeiffer syndrome (PS) [MIM:101600]; also known as acrocephalosyndactyly type V (ACS5). PS is characterized by craniosynostosis (premature fusion of the skull sutures) with deviation and enlargement of the thumbs and great toes, brachymesophalangy, with phalangeal ankylosis and a varying degree of soft tissue syndactyly. & Defects in FGFR1 are a cause of isolated hypogonadotropic hypogonadism (IHH) [MIM:146110]. Hypogonadism is a condition characterized by abnormally decreased gonadal function, with retardation of growth and sexual development. Hypogonadotropic hypogonadism is due to inadequate secretion of gonadotropins. It results from failure to release sufficient gonadotropin-releasing hormone. & Defects in FGFR1 are the cause of Kallmann syndrome type 2 (KAL2) [MIM:147950]; also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin- releasing hormone-synthesizing neurons. In some cases, midline cranial anomalies (cleft lip/palate and imperfect fusion) are present and anosmia may be absent or inconspicuous. & Defects in FGFR1 are the cause of osteoglophonic dysplasia (OGD) [MIM:166250]; also known as osteoglophonic dwarfism. OGD is characterized by craniosynostosis, prominent supraorbital ridge, and depressed nasal bridge, as well as by rhizomelic dwarfism and nonossifying bone lesions. Inheritance is autosomal dominant. & Defects in FGFR1 are the cause of non-syndromic trigonocephaly [MIM:190440]; also known as metopic craniosynostosis. The term trigonocephaly describes the typical keel-shaped deformation of the forehead resulting from premature fusion of the frontal suture. Trigonocephaly may occur also as a part of a syndrome. & A chromosomal aberration involving FGFR1 may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Translocation t(8;13)(p11;q12) with ZMYM2. SCLL usually presents as lymphoblastic lymphoma in association with a myeloproliferative disorder, often accompanied by pronounced peripheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow. & A chromosomal aberration involving FGFR1 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1OP. Insertion ins(12;8)(p11;p11p22) with FGFR1OP2. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP2-FGFR1, FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity.
      SIMILARITY: SwissProt: P11362 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. & Contains 3 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
      Molecular Weight110 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated in sFGFR-1 (obtained from Alexis® Biochemicals, Catalog # SFC-015)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C or 2 months at 4°C
      Packaging Information
      Material Size250 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-FGF R-1 (Flg), clone 19B2 (mouse monoclonal IgG1) - 2142245 2142245
      Anti-FGF R-1 (Flg), clone 19B2 (mouse monoclonal IgG1) - 2382626 2382626
      Anti-FGF R-1 (Flg), clone 19B2 (mouse monoclonal IgG1) - DAM1810793 DAM1810793
      Anti-FGF R-1 (Flg), clone 19B2 - 2510359 2510359
      Anti-FGF R-1 (Flg), clone 19B2 - DAM1636061 DAM1636061
      Anti-FGF R-1 (Flg), clone 19B2 - DAM1780349 DAM1780349
      Anti-FGF R-1 (Flg), clone 19B2 - JBC1839879 JBC1839879
      Anti-FGF R-1 (Flg), clone 19B2 - JBC1879889 JBC1879889
      Anti-FGF R-1 (Flg), clone 19B2 -2691199 2691199
      Anti-FGF R-1 (Flg), clone 19B2 -2714536 2714536

      References

      Reference overviewApplicationPub Med ID
      Activation of glial FGFRs is essential in glial migration, proliferation, and survival and in glia-neuron signaling during olfactory system development.
      Gibson, NJ; Tolbert, LP; Oland, LA
      PloS one  7  e33828  2012

      Show Abstract
      22493675 22493675
      Alpha sarcoglycan is required for FGF-dependent myogenic progenitor cell proliferation in vitro and in vivo.
      Cassano, M; Dellavalle, A; Tedesco, FS; Quattrocelli, M; Crippa, S; Ronzoni, F; Salvade, A; Berardi, E; Torrente, Y; Cossu, G; Sampaolesi, M
      Development (Cambridge, England)  138  4523-33  2011

      Show Abstract
      21903674 21903674
      Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner
      Reilly, J. F., et al
      J Biol Chem, 275:7771-8 (2000)  2000

      Immunoblotting (Western)10713090 10713090
      Fibroblast growth factor (FGF) soluble receptor 1 acts as a natural inhibitor of FGF2 neurotrophic activity during retinal degeneration
      Guillonneau, X., et al
      Mol Biol Cell, 9:2785-802 (1998)  1998

      Immunoprecipitation9763444 9763444
      Up-regulation of fibroblast growth factor receptor-1 in lens epithelial cells paralleled by growth stimulation.
      T Marunouchi, H Hosoya, T Morioku, T Mori, Y Majima, M Kousaka
      Experimental eye research  67  611-6  1998

      9878224 9878224
      Suppression of fibroblast growth factor receptor signaling inhibits pancreatic cancer growth in vitro and in vivo.
      M Wagner, M E Lopez, M Cahn, M Korc
      Gastroenterology  114  798-807  1998

      Show Abstract
      9516401 9516401
      Expression of a dominant negative FGF receptor inhibits axonal growth and FGF receptor phosphorylation stimulated by CAMs
      Saffell, J. L., et al
      Neuron, 18:231-42 (1997)  1997

      Immunoblotting (Western)9052794 9052794
      Differential modulation of basic fibroblast and epidermal growth factor receptor activation by ganglioside GM3 in cultured retinal Müller glia.
      Meuillet, E, et al.
      Glia, 17: 206-16 (1996)  1996

      Show Abstract
      Cell Culture8840162 8840162
      Expression and immunochemical analysis of rat and human fibroblast growth factor receptor (flg) isoforms.
      Xu, J, et al.
      J. Biol. Chem., 267: 17792-803 (1992)  1992

      Show Abstract
      1325449 1325449
      Fibroblast growth factor receptors from liver vary in three structural domains.
      Hou, J Z, et al.
      Science, 251: 665-8 (1991)  1991

      Show Abstract
      1846977 1846977

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies