05-1512 | Anti-FMR1 Antibody, clone 6A15

05-1512
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      DrWBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-1512
      DescriptionAnti-FMR1 Antibody, clone 6A15
      Alternate Names
      • Protein FMR-1
      • fragile X mental retardation 1
      • premature ovarian failure 1
      Background InformationFragile X Mental Retardation 1 (FMR1) is a RNA-binding protein that is associated to polysomes and may be involved in the transport of mRNA from the nucleus to the cytoplasm. Defects in FMR1 are the cause of Fragile X syndrome, which is a common genetic disease characterized by moderate to severe mental retardation, macroorchidism, large ears, prominent jaw, and high-pitched, jocular speech. The defect in most fragile X syndrome patients results from an amplification of a CGG repeat region which is directly in front of the coding region.
      References
      Product Information
      FormatPurified
      Control
      • Drosophila Schneider L2 cell lysate
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Applications
      ApplicationAnti-FMR1 Antibody, clone 6A15 is an antibody against FMR1 for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenHis-tagged recombinant protein corresponding to Drosophila FMR1.
      EpitopeUnknown
      Clone6A15
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody recognizes FMR1.
      IsotypeIgG1κ
      Species Reactivity
      • Drosophila
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FMR1
      • FMRP
      • FRAXA
      • POF
      • POF1
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: RNA-binding protein that associates with translating ribosomes and acts as a negative translational regulator of specific mRNAs. Represses translation of futsch to regulate microtubule-dependent synaptic growth and function. Part of the RNA interference (RNAi)-related apparatus; double-stranded RNA induces potent and specific gene silencing. Regulates photoreceptor structure and neurotransmission in the eye. Required for stability of the central pair of microtubules in the spermatid axoneme.

      SUBUNIT STRUCTURE: Homodimer. Interacts with futsch and Sra-1. Interacts with the ribosome to form a ribonucleoprotein (RNP) complex, involved in translation regulation, with mRpL5 and mRpL11 on the ribosomal surface. The complex also contains AGO2, Dcr-1 and Rm62.

      SUBCELLULAR LOCATION: Cytoplasm.

      TISSUE SPECIFICITY: Until early gastrulation, expression is uniformly distributed in the embryo. At mid-gastrulation (stage 11), expression everywhere with discernible concentration in the mesoderm. After gastrulation (stage 14), expression is significantly elevated in the mesoderm, ventral nerve cord, and brain. At stage 16, elevated expression is also seen in the muscle. Highly expressed in nervous system throughout later development. Highly expressed in testes in the early stages of spermatogenesis before spermatid individualization.

      DEVELOPMENTAL STAGE: Expressed both maternally and zygotically in embryos.

      SEQUENCE SIMILARITIES: Belongs to the FMR1 family.

      Contains 2 KH domains.
      Molecular Weight85 kDa was observed; however, additional bands were observed at 50, 55, and 80 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in Drosophila Schneider L2 cell lysate.

      Western Blot Analysis: 0.1 µg/ml of this antibody detected FMR1 on 10 µg of Drosophila Schneider L2 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications