07-1825 | Anti-FRS3/FRS2β Antibody

07-1825
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-1825
      DescriptionAnti-FRS3/FRS2β Antibody
      Alternate Names
      • FGFR substrate 3
      • FGFR-signaling adaptor SNT2
      • Suc1-associated neurotrophic factor target 2
      • fibroblast growth factor receptor substrate 3
      • suc1-associated neurotrophic factor target 2 (FGFR
        signalling adaptor)
      Background InformationFibroblast growth factor receptor substrate 3 (FRS3) is an adapter protein that is tyrosine phosphorylated and recruited to FGFR upon FGF stimulation. FRS3 is also designated as FRS2 and SNT2 (Suc1 associated neurotrophic factor target protein).
      References
      Product Information
      FormatAffinity Purified
      Control
      • Mouse brain tissue lysate
      PresentationPurified rabbit serum in PBS containing 0.05% sodium azide.
      Applications
      ApplicationAnti-FRS3/FRS2β Antibody detects level of FRS3/FRS2β & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to amino acids 361-375 of FRS3/ FRS2β.
      EpitopePTB
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes FRS3/ FRS2β.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteProven to react with human, mouse, and rat.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FRS2-beta
      • FRS2B
      • FRS2beta
      • MGC17167
      • OTTHUMP00000016383
      • OTTHUMP00000039786
      • SNT-2
      • SNT2
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.

      SUBUNIT STRUCTURE: Binds NTRK1 By similarity. Binds FGFR1, NGFR, GRB2, PTPN11 and ERK2.

      SUBCELLULAR LOCATION: Membrane; Lipid-anchor.

      PTM: Phosphorylated on tyrosine residues upon stimulation by BFGF or NGFB.

      SEQUENCE SIMILARITIES: Contains 1 IRS-type PTB domain.

      Molecular Weight54 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in mouse brain tissue lysate.

      Western Blot Analysis: A 1:2,000 dilution of this antibody detected FRS3/ FRS2β in mouse brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C for 1 year from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-FRS3/FRS2 - 1959698 1959698
      Anti-FRS3/FRS2 - NG1624967 NG1624967
      Anti-FRS3/FRS2β - 2379305 2379305
      Anti-FRS3/FRS2β - 2459512 2459512

      References

      Reference overviewPub Med ID
      The fibroblast growth factor receptor substrate 3 adapter is a developmentally regulated microtubule-associated protein expressed in migrating and differentiated neurons.
      Hryciw T, MacDonald JI, Phillips R, Seah C, Pasternak S, Meakin SO
      J Neurochem  112  924-39. Epub 2009 Nov 24.  2010

      Show Abstract
      19943849 19943849