05-1529 | Anti-FXR1 Antibody, clone 6BG10

05-1529
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, ICC, IPMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-1529
      DescriptionAnti-FXR1 Antibody, clone 6BG10
      Alternate Names
      • fragile X mental retardation, autosomal homolog 1
      • fragile X mental retardation-related protein 1
      Background InformationFragile X mental retardation-related protein 1 (FXR1) and FXR2 are members of the FMR1 family sharing a very high degree of protein similarity among them. They interact with each other and also with FMR1, moving between the cytoplasm and the nucleus. FXR1 is an RNA binding protein and is expressed in the heart, kidney, brain, and testis. Mutations in FMR1 result in the most common form of mental retardation.
      References
      Product Information
      FormatPurified
      Control
      • HeLa cell lysate
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Applications
      ApplicationUse Anti-FXR1 Antibody, clone 6BG10 (Mouse Monoclonal Antibody) validated in WB, ICC, IP to detect FXR1 also known as fragile X mental retardation autosomal homolog 1.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Immunoprecipitation
      Application NotesImmunocytochemistry Analysis: 1:500 dilution from a representative lot detected FXR1 in HeLa and NIH/3T3 cell lysates.

      Immunoprecipitation Analysis: A representative lot was used in an independent laboratory in immunoprecipitation. Siomi, M., et al. (1996). Molecular and Cellular Biology. 3825-3832.
      Biological Information
      ImmunogenRecombinant protein corresponding to human FXR1.
      EpitopeUnknown
      Clone6BG10
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody recognizes FXR1.
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
      Gene Symbol
      • FXR1
      • hFXR1
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs By similarity.

      SUBUNIT STRUCTURE: Interacts with FMR1 and FXR2. Interacts with TDRD3, and with CYFIP2 but not with CYFIP1.

      SUBCELLULAR LOCATION: Cytoplasm.

      TISSUE SPECIFICTY: Expressed in all tissues examined including heart, brain, kidney and testis.

      PTM: Arg-445 is dimethylated, probably to asymmetric dimethylarginine.

      SEQUENCE SIMILARITIES: Belongs to the FMR1 family.

      Contains 2 KH domains.
      Molecular Weight68 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HeLa cell lysate.

      Western Blot Analysis: 0.5 µg/ml of this antibody detected FXR1 on 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-FXR1, clone 6BG10 - 2430454 2430454
      Anti-FXR1, clone 6BG10 - 2051972 2051972
      Anti-FXR1, clone 6BG10 - 2884656 2884656
      Anti-FXR1, clone 6BG10 - NG1720745 NG1720745
      Anti-FXR1, clone 6BG10 - NG1853781 NG1853781
      Anti-FXR1, clone 6BG10 - NG1946561 NG1946561
      Anti-FXR1, clone 6BG10 - NRG1655005 NRG1655005
      Anti-FXR1, clone 6BG10 -2512443 2512443
      Anti-FXR1, clone 6BG10 -2649102 2649102
      Anti-FXR1, clone 6BG10 -2726704 2726704

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies