04-470 | Anti-Farnesyltransferase Antibody, α subunit (FNTA), clone 2418

100 µL  
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      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Catalogue Number04-470
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Farnesyltransferase Antibody, α subunit (FNTA), clone 2418
      Alternate Names
      • farnesyltransferase
      • CAAX box, alpha
      • FTase-alpha
      • GGTase-I-alpha
      • farnesyltransferase alpha-subunit
      • ras proteins prenyltransferase alpha
      Product Information
      Presentation100 μL of protein A purified mouse monoclonal IgG1κ in PBS with 0.1% sodium azide.
      ApplicationDetect Farnesyltransferase using this Anti-Farnesyltransferase Antibody, α subunit (FNTA), clone 2418 validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenFull length GST-farnesyltransferase, alpha subunit protein
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificitySpecific to the alpha subunit of farnesyl transferase.
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryPrenyltransferases attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of protein's with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants encoding different isoforms.
      Gene Symbol
      • FNTA
      • FPTA
      • MGC99680
      • FTase-alpha
      • GGTase-I-alpha
      • PGGT1A
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P49354 # Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate.
      SIZE: 379 amino acids; 44409 Da
      SUBUNIT: Heterodimer of an alpha and a beta subunit.
      SIMILARITY: SwissProt: P49354 ## Belongs to the protein prenyltransferase subunit alpha family. & Contains 5 PFTA repeats.
      Molecular Weight44 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/ thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Farnesyltransferase, #945; subunit (FNTA), clone 2418 - 2148494 2148494
      Anti-Farnesyltransferase, a subunit (FNTA), clone 2418 (Protein A purified Mouse Monoclonal) - 2365793 2365793
      Anti-Farnesyltransferase, alpha; subunit (FNTA), clone 2418 - 0611044482 0611044482
      Anti-Farnesyltransferase,  subunit (FNTA), clone 2418 -2569345 2569345


      Reference overviewPub Med ID
      Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter
      Delarue FL, Adnane J, Joshi B, Blaskovich MA, Wang DA, Hawker J, Bizouarn F, Ohkanda J, Zhu K, Hamilton AD, Chellappan S, Sebti SM.
      Delarue, F L, et al  2006

      16909123 16909123
      Effects of the farnesyl transferase inhibitor R115777 (Zarnestra) on mammary carcinogenesis: prevention, therapy, and role of HaRas mutations
      Lubet, Ronald A, et al
      Mol Cancer Ther, 5:1073-8 (2006)  2006

      16648579 16648579