05-491 | Anti-FcεRI α subunit Antibody, clone 3G6

05-491
200 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIPMAscitesMonoclonal Antibody
      Description
      Catalogue Number05-491
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-FcεRI α subunit Antibody, clone 3G6
      References
      Product Information
      FormatAscites
      Presentationmouse ascites containing 0.05% sodium azide
      Applications
      ApplicationAnti-FcεRI α subunit Antibody, clone 3G6 detects level of FcεRI α subunit & has been published & validated for use in IP.
      Key Applications
      • Immunoprecipitation
      Application NotesNot recommended for WB.
      Biological Information
      ImmunogenTransfected cells expressing the α-chain of the human high-affinity receptor for immunoglobulin E (FcεRI)
      Clone3G6
      HostMouse
      SpecificityHuman FcεRI α
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more high-affinity IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha, beta (MIM 147138), and gamma (MIM 147139); only the alpha subunit is glycosylated.[supplied by OMIM]
      Gene Symbol
      • FCER1A
      • FcERI
      • FCE1A
      Purification MethodAscites
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P12319 # Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
      SIZE: 257 amino acids; 29596 Da
      SUBUNIT: Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      SIMILARITY: SwissProt: P12319 ## Contains 2 Ig-like (immunoglobulin-like) domains.
      Molecular Weight45kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoprecipitation of the FcεRI α chain from transfected CHO lysate, subsequent immunobloting with anti-FcεRI α (Catalog #06-725)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Fc#949;RI #945;, clone 3G6 (mouse ascites) - 2135166 2135166
      Anti-FceRI a, clone 3G6 (mouse ascites) - 2246072 2246072
      Anti-Fcepsilon;RI alpha; subunit , clone 3G6 - 17544 17544
      Anti-Fcepsilon;RI alpha; subunit , clone 3G6 - 20762 20762
      Anti-Fcepsilon;RI alpha; subunit , clone 3G6 - 24851 24851

      References

      Reference overviewPub Med ID
      Glycosylation of human truncated Fc epsilon RI alpha chain is necessary for efficient folding in the endoplasmic reticulum.
      Letourneur, O, et al.
      J. Biol. Chem., 270: 8249-56 (1995)  1995

      Show Abstract
      7713932 7713932

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      06-725-I Anti-FcεRI α subunit Antibody Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies