05-859 | Anti-Fibrinogen Antibody, clone GMA-035

05-859
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISA, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-859
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Fibrinogen Antibody, clone GMA-035
      References
      Product Information
      FormatPurified
      Applications
      ApplicationThis Anti-Fibrinogen Antibody, clone GMA-035 is validated for use in ELISA, WB for the detection of Fibrinogen.
      Key Applications
      • ELISA
      • Western Blotting
      Biological Information
      ImmunogenPurified human fibrinogen
      CloneGMA-035
      HostMouse
      Specificityfibrinogen
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.
      Gene Symbol
      • FGA
      • MGC119423
      • Fib2
      • MGC119422
      • MGC119425
      Purification MethodDEAE purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P02679 # Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
      SIZE: 453 amino acids; 51512 Da
      SUBUNIT: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain (By similarity).
      SUBCELLULAR LOCATION: Secreted.
      DOMAIN: SwissProt: P02679 A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
      PTM: Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon- (gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. & Sulfation of C-terminal tyrosines increases affinity for thrombin.DISEASE:SwissProt: P02679 # Defects in FGG are a cause of thrombophilia. & Defects in FGG are a cause of congenital afibrinogenemia [MIM:202400]. It is a rare autosomal recessive disorder characterized by complete absence of detectable fibrinogen.
      SIMILARITY: Contains 1 fibrinogen C-terminal domain.
      MISCELLANEOUS: The gamma-chain carries the main binding site for the platelet receptor.
      Molecular WeightMr 340kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on human fibrinogen
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditionsstable 2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Fibrinogen, clone GMA-035 (mouse monoclonal IgG1) - 2109542 2109542
      Anti-Fibrinogen, clone GMA-035 (mouse monoclonal IgG1) - 2140049 2140049
      Anti-Fibrinogen, clone GMA-035 (mouse monoclonal IgG1) - 2179343 2179343
      Anti-Fibrinogen, clone GMA-035 - 1945595 1945595
      Anti-Fibrinogen, clone GMA-035 - 1970723 1970723
      Anti-Fibrinogen, clone GMA-035 - 2041588 2041588
      Anti-Fibrinogen, clone GMA-035 - 2058361 2058361
      Anti-Fibrinogen, clone GMA-035 - 27177 27177
      Anti-Fibrinogen, clone GMA-035 - DAM1564515 DAM1564515
      Anti-Fibrinogen, clone GMA-035 - NG143002 NG143002

      References

      Reference overviewPub Med ID
      Genome-wide mapping of histone H4 serine-1 phosphorylation during sporulation in Saccharomyces cerevisiae.
      Govin, J; Schug, J; Krishnamoorthy, T; Dorsey, J; Khochbin, S; Berger, SL
      Nucleic acids research  38  4599-606  2010

      Show Abstract Full Text Article
      20375100 20375100
      X-ray crystallographic studies on fibrinogen and fibrin.
      Doolittle, R F
      J. Thromb. Haemost., 1: 1559-65 (2003)  2003

      Show Abstract
      12871291 12871291
      Fibrinogen: biochemistry, epidemiology and determinants.
      Kamath, S and Lip, G Y H
      QJM : monthly journal of the Association of Physicians, 96: 711-29 (2003)  2003

      14500858 14500858
      Hereditary disorders of fibrinogen.
      Matsuda, M and Sugo, T
      Ann. N. Y. Acad. Sci., 936: 65-88 (2001)  2001

      Show Abstract
      11460526 11460526