05-1134 | Anti-Fibroblast Growth Factor Receptor 1 Antibody, clone VBS1

05-1134
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R, Ch, BWB, IP, IH(P), ELISAMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-1134
      ReplacesMAB125
      DescriptionAnti-Fibroblast Growth Factor Receptor 1 Antibody, clone VBS1
      Alternate Names
      • CD331 antigen
      • Fms-like tyrosine kinase 2
      • basic fibroblast growth factor receptor 1
      • fibroblast growth factor receptor 1
      • fms-related tyrosine kinase 2
      • heparin-binding growth factor receptor
      • hydroxyaryl-protein kinase
      • soluble FGFR1 variant 1
      • soluble FGFR1 variant 2
      Background InformationThe fibroblast growth factor receptors are members of the tyrosine kinase superfamily and consist of an extracellular ligand domain composed of three immunoglobulin-like domains, a single transmembrane helix domain, and an intracellular domain with tyrosine kinase activity. (Ornitz, DM. and Itoh, N) Monoclonal antibodies against the high affinity tyrosine kinase Fibroblast Growth Factor (FGF) receptor may help define receptor epitopes involved in FGF binding and signal transduction which mediate coronary and tumor angiogenesis. (Venkateswaran, S., et al).
      References
      Product Information
      FormatPurified
      Control
      • NIH/3T3 cell lysate
      PresentationPurified mouse monoclonal IgM in 0.015 M potassium phosphate buffer containing 0.15 M NaCl, 0.1% sodium azide, pH 7.20.
      Applications
      ApplicationDetect Fibroblast Growth Factor Receptor 1 using this Anti-Fibroblast Growth Factor Receptor 1 Antibody, clone VBS1 validated for use in WB, IP, IH(P), ELISA.
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      • Immunohistochemistry (Paraffin)
      • ELISA
      Application NotesImmunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH(P) (Venkateswaran, S., et al)
      Biological Information
      ImmunogenFGF Receptor purified from bovine coronary venular endothelial cells.
      EpitopeExtracellular
      CloneVBS1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody recognizes the extracellular ligand-binding domain of Fibroblast Growth Factor Receptor 1.
      IsotypeIgM
      Species Reactivity
      • Human
      • Mouse
      • Rat
      • Chicken
      • Bovine
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CD331
      • CEK
      • EC 2.7.10.1
      • FGFBR
      • FGFR-1
      • FLG
      • FLJ99988
      • FLT2
      • H2
      • H3
      • H4
      • H5
      • HBGFR
      • KAL2
      • N-SAM
      • OGD
      • OTTHUMP00000190874
      • OTTHUMP00000190878
      • OTTHUMP00000190879
      • OTTHUMP00000190881
      • bFGF-R
      • c-fgr
      • BFGFR
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Receptor for basic fibroblast growth factor. Receptor for FGF23 in the presence of KL By similarity. A shorter form of the receptor could be a receptor for FGF1 (aFGF).
      CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
      SUBUNIT STRUCTURE: Interacts with SHB. Interacts with KLB By similarity. Interacts with KL and FGF23 By similarity.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells.
      PTM: Binding of FGF1 and heparin promotes autophosphorylation on tyrosine residues and activation of the receptor.
      INVOLVEMENTI IN DISEASE: Defects in FGFR1 are a cause of Pfeiffer syndrome (PS) [MIM:101600]; also known as acrocephalosyndactyly type V (ACS5). PS is characterized by craniosynostosis (premature fusion of the skull sutures) with deviation and enlargement of the thumbs and great toes, brachymesophalangy, with phalangeal ankylosis and a varying degree of soft tissue syndactyly.
      Defects in FGFR1 are a cause of idiopathic hypogonadotropic hypogonadism (IHH) [MIM:146110]. IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function.
      Defects in FGFR1 are the cause of Kallmann syndrome type 2 (KAL2) [MIM:147950]; also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some cases, midline cranial anomalies (cleft lip/palate and imperfect fusion) are present and anosmia may be absent or inconspicuous.
      Defects in FGFR1 are the cause of osteoglophonic dysplasia (OGD) [MIM:166250]; also known as osteoglophonic dwarfism. OGD is characterized by craniosynostosis, prominent supraorbital ridge, and depressed nasal bridge, as well as by rhizomelic dwarfism and nonossifying bone lesions. Inheritance is autosomal dominant.
      Defects in FGFR1 are the cause of non-syndromic trigonocephaly [MIM:190440]; also known as metopic craniosynostosis. The term trigonocephaly describes the typical keel-shaped deformation of the forehead resulting from premature fusion of the frontal suture. Trigonocephaly may occur also as a part of a syndrome.
      A chromosomal aberration involving FGFR1 may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Translocation t(8;13)(p11;q12) with ZMYM2. SCLL usually presents as lymphoblastic lymphoma in association with a myeloproliferative disorder, often accompanied by pronounced peripheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow.
      A chromosomal aberration involving FGFR1 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1OP. Insertion ins(12;8)(p11;p11p22) with FGFR1OP2. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP2-FGFR1, FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity.
      A chromosomal aberration involving FGFR1 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(8;9)(p12;q33) with CEP110. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein CEP110-FGFR1 is found in the cytoplasm, exhibits constitutive kinase activity and may be responsible for the transforming activity.
      SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
      Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 1 protein kinase domain.
      Molecular Weight~92 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in NIH/3T3 cell lysate.
      Western Blotting Analysis: 0.78 µg/mL of this antibody detected Fibroblast Growth Factor Receptor 1 in 10 µg of NIH/3T3 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Fibroblast Growth Factor -2688495 2688495
      Anti-Fibroblast Growth Factor -2814746 2814746
      Anti-Fibroblast Growth Factor Receptor 1, clone VBS1 - 2382645 2382645
      Anti-Fibroblast Growth Factor Receptor 1, clone VBS1 - 2477978 2477978
      Anti-Fibroblast Growth Factor Receptor 1, clone VBS1 - NG1809963 NG1809963
      Anti-Fibroblast Growth Factor Receptor 1, clone VBS1 - NG1840148 NG1840148
      Anti-Fibroblast Growth Factor Receptor 1, clone VBS1 - NG1853793 NG1853793
      Anti-Fibroblast Growth Factor Receptor 1, clone VBS1 - NRG1695399 NRG1695399
      Anti-Fibroblast Growth Factor Receptor 1, clone VBS1 -2564848 2564848
      Anti-Fibroblast Growth Factor Receptor 1, clone VBS1 -2603813 2603813

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies