06-670 | Anti-Flt-1 Antibody, CT

06-670
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBChPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-670
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Flt-1 Antibody, CT
      References
      Product Information
      FormatPurified
      Presentationsterile PBS, 0.05% sodium azide
      Applications
      ApplicationAnti-Flt-1 Antibody, CT detects level of Flt-1 & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      Immunogen22 residue synthetic peptide (DDVRYVNAFKFMSLERIKTFEE) corresponding to amino acids 1209-1230 of human Flt-1
      HostChicken
      SpecificityFlt-1
      IsotypeIgY
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryOncogene FLT belongs to the src gene family and is related to oncogene ROS (MIM 165020). Like other members of this family, it shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The sequence structure of the FLT gene resembles that of the FMS gene (MIM 164770); hence, Yoshida et al. (1987) proposed the name FLT as an acronym for FMS-like tyrosine kinase.[supplied by OMIM]
      Gene Symbol
      • FLT1
      • VEGFR1
      • FLT
      • FRT
      • VEGFR-1
      • Flt-1
      Purification MethodPEG and Ammonium Sulfate precipitation
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P17948 # Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis.
      SIZE: 1338 amino acids; 150769 Da
      SUBUNIT: Interacts in vitro with various phosphotyrosine-binding proteins, including PLC-gammas, PTPN11, GRB2, CRK and NCK1.
      SUBCELLULAR LOCATION: Isoform Flt1: Cell membrane; Single-pass type I membrane protein. & Isoform sFlt1: Secreted.
      TISSUE SPECIFICITY: Mostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. It is not expressed in tumor cell lines. Isoform sFlt1 is strongly expressed in placenta.
      SIMILARITY: SwissProt: P17948 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 7 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
      Molecular Weight180 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on a membrane preparation from Hi5 insect cells expressing recombinant Flt-1
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificates of Analysis

      TitleLot Number
      Anti-Flt-1, CT - 16231 16231
      Anti-Flt-1, CT - 18374 18374
      Anti-Flt-1, CT - 32206 32206

      References

      Reference overviewPub Med ID
      Development of vascular endothelial growth factor receptor (VEGFR) kinase inhibitors as anti-angiogenic agents in cancer therapy.
      Underiner, T L, et al.
      Curr. Med. Chem., 11: 731-45 (2004)  2004

      Show Abstract
      15032727 15032727
      Vascular endothelial growth factor: basic science and clinical progress.
      Ferrara, Napoleone
      Endocr. Rev., 25: 581-611 (2004)  2004

      Show Abstract
      15294883 15294883
      Receptor chimeras indicate that the vascular endothelial growth factor receptor-1 (VEGFR-1) modulates mitogenic activity of VEGFR-2 in endothelial cells.
      Rahimi, N, et al.
      J. Biol. Chem., 275: 16986-92 (2000)  2000

      Show Abstract
      10747927 10747927

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies