06-647 | Anti-Flt-3 Antibody, cytoplasmic domain

06-647
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MIP, WB, ICCRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-647
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Flt-3 Antibody, cytoplasmic domain
      References
      Product Information
      FormatPurified
      Presentation0.07M Tris-glycine, pH 7.4, 0.105M NaCl and 0.035% sodium azide, and 30% glycerol.
      Applications
      ApplicationAnti-Flt-3 Antibody, cytoplasmic domain is an antibody against Flt-3 for use in IP, WB & IC.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      • Immunocytochemistry
      Biological Information
      ImmunogenHis-tag fusion protein corresponding to residues 786-1000 of mouse Flt3
      HostRabbit
      Specificitypremature and the mature forms of Flt3
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
      Gene Symbol
      • FLT3
      • STK-1
      • CD135
      • FLK2
      • OTTHUMP00000042340
      • STK1
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P36888 # Receptor for the FL cytokine. Has a tyrosine-protein kinase activity.
      SIZE: 993 amino acids; 112903 Da
      SUBUNIT: Interacts with FIZ1 following ligand activation (By similarity).
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Bone marrow cells.
      SIMILARITY: SwissProt: P36888 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 1 Ig-like C2-type (immunoglobulin-like) domain. & Contains 1 protein kinase domain.
      Molecular Weightpremature (130kDa) and the mature form (155kDa)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from HeLa cells or mouse Bafl-3 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificates of Analysis

      TitleLot Number
      Anti-Flt-3, cytoplasmic domain - 16238 16238
      Anti-Flt-3, cytoplasmic domain - 28692 28692
      Anti-Mouse Flt3 cytoplasmic domain (130 155kDa) (rabbit polyclonal IgG) - 2262773 2262773
      Anti-Mouse Flt3 cytoplasmic domain (130 155kDa) - 2056000 2056000
      Anti-Mouse Flt3 cytoplasmic domain (130 & 155kDa) -2507256 2507256
      Anti-Mouse Flt3 cytoplasmic domain (130 & 155kDa) -2679365 2679365
      Anti-Mouse Flt3 cytoplasmic domain (130 & 155kDa) -2750290 2750290
      Anti-Mouse Flt3 cytoplasmic domain (130 & 155kDa) -2757886 2757886
      Anti-Mouse Flt3 cytoplasmic domain (130 & 155kDa) -2769021 2769021
      Anti-Mouse Flt3 cytoplasmic domain (130 & 155kDa) -2789877 2789877

      References

      Reference overviewPub Med ID
      FMS-like tyrosine kinase 3-internal tandem duplication tyrosine kinase inhibitors display a nonoverlapping profile of resistance mutations in vitro.
      Nikolas von Bubnoff,Richard A Engh,Espen Aberg,Jana Sänger,Christian Peschel,Justus Duyster
      Cancer research  69  2009

      Show Abstract
      19318574 19318574
      Phosphatidylinositol-3' kinase is not required for mitogenesis or internalization of the Flt3/Flk2 receptor tyrosine kinase.
      Beslu, N, et al.
      J. Biol. Chem., 271: 20075-81 (1996)  1996

      8702727 8702727
      Biochemical characterization and analysis of the transforming potential of the FLT3/FLK2 receptor tyrosine kinase.
      Maroc, N, et al.
      Oncogene, 8: 909-18 (1993)  1993

      Show Abstract
      8384358 8384358