04-968 | Anti-Folr4 (Folate receptor 4) Antibody, clone 5E12.2

04-968
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-968
      DescriptionAnti-Folr4 (Folate receptor 4) Antibody, clone 5E12.2
      Alternate Names
      • folate receptor 4 (delta) homolog (mouse)
      • folate receptor 4 (delta) homolog
      • Folate receptor 4
      Background InformationFolates are necessary and critical components in the synthesis of proteins and nucleic acids, and have putative roles in the development of both the spinal canal and brain in the early stages of pregnancy (Yamaguchi, 2007). Folate receptor 4 (Folr4) is a recently discovered cell surface receptor for folic acid on T regulatory cells (Tregs). Studies have shown that Folr4 has an integral role in the maintenance of Treg cell function (Arase, 2009). Expression of Folr4 in Tregs is notably high, making it an opportune marker for the study of Treg cells. When studied in conjunction with CD4 and CD25, Folr4 also provides researchers with a marker to distinguish between Tregs and other T cells (Chai, 2008). Tregs are of interest in therapeutic, drug research due to their ability to actively suppress immune responses.
      References
      Product Information
      FormatPurified
      Control
      • Human thymus tissue lysate
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Applications
      ApplicationAnti-Folr4 (Folate receptor 4) Antibody, clone 5E12.2 detects level of Folr4 (Folate receptor 4) & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern Blot (SNAP ID) Analysis: 1 µg/mL of this antibody detected Folate receptor 4 (Folr4) in 10 µg of human thymus tissue lysate.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Folate receptor 4 (Folr4).
      EpitopeUnknown
      Clone5E12.2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody recognizes Folate receptor 4 (Folr4).
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Folbp3
      • Folr4
      • FR-delta
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummarySUBCELLULAR LOCATION: Secreted Potential.

      PTM: Eight disulfide bonds are present Potential.

      SEQUENCE SIMILARITIES: Belongs to the folate receptor family.
      Molecular Weight~26 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human thymus tissue lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected Folate receptor 4 (Folr4) in 10 µg of human thymus tissue lysate.
      A previous lot was shown to detect Folate Receptor 4 in mouse thymus tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Folr4 (Folate receptor 4), clone 5E12.2 - 2376670 2376670
      Anti-Folr4 (Folate receptor 4), -2669849 2669849
      Anti-Folr4 (Folate receptor 4), -2723534 2723534
      Anti-Folr4 (Folate receptor 4), -2726180 2726180
      Anti-Folr4 (Folate receptor 4), -2732607 2732607
      Anti-Folr4 (Folate receptor 4), -2766381 2766381
      Anti-Folr4 (Folate receptor 4), clone 5E12.2 PRODUCT
      Anti-Folr4 (Folate receptor 4), clone 5E12.2 - NRG1721908 NRG1721908
      Anti-Folr4 (Folate receptor 4), clone 5E12.2 Monoclonal Antibody 2869699
      Anti-Folr4 (Folate receptor 4),clone 5E12.2 -2739021 2739021