06-341 | Anti-Fos Antibody

06-341
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MIP, WB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-341
      ReplacesCBL441
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Fos Antibody
      Background InformationThe v-Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phospho-protein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA response elements, c-Fos proteins are only active as heterodimers with members of the Jun gene family. Functional homologs of c-Fos include the Fra-1, Fra-2 and Fos B genes. In addition, selected ATF/CREB family members can form leucine zipper dimers with Fos and Jun. Different dimers exhibit differential specificity and affinity for AP-1 and CRE sites.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Serum-stimulated Hela cell lysate, phorbol ester-treated and EGF-treated A-431 nuclear cell extracts
      PresentationPBS containing 2mg/ml BSA and 0.2% sodium azide
      Applications
      ApplicationDetect Fos with Anti-Fos Antibody (Rabbit Polyclonal Antibody), that has been shown to work in IP, WB, ICC.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      • Immunocytochemistry
      Biological Information
      ImmunogenTrp E fusion-protein corresponding to the N-terminal fragment containing amino acid residues 75-155 of human v-Fos
      HostRabbit
      Specificityc-Fos and v-Fos
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death.
      Gene Symbol
      • FOS
      • G0S7
      • c-fos
      Purification MethodImmunoaffinity Chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01100 # Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, c-fos and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.
      SIZE: 380 amino acids; 40695 Da
      SUBUNIT: Heterodimer with JUN. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with MAFB (By similarity).
      SUBCELLULAR LOCATION: Nucleus.
      SIMILARITY: SwissProt: P01100 ## Belongs to the bZIP family. Fos subfamily. & Contains 1 bZIP domain.
      Molecular Weight55kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysate of human HeLa nuclear extract
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at -20°C
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Fos - 0701049687 0701049687
      Anti-Fos - 15647 15647
      Anti-Fos - 16476 16476
      Anti-Fos - 17744 17744
      Anti-Fos - 19958 19958
      Anti-Fos - 20924 20924
      Anti-Fos - 23255 23255
      Anti-Fos - 24867 24867
      Anti-Fos - 26342 26342
      Anti-Fos - 29947 29947

      References

      Reference overviewApplicationPub Med ID
      Mitochondrial calcium uptake capacity as a therapeutic target in the R6/2 mouse model of Huntington's disease.
      Perry GM, Tallaksen-Greene S, Kumar A, Heng MY, Kneynsberg A, van Groen T, Detloff PJ, Albin RL, Lesort M
      Hum Mol Genet  2010

      Show Abstract
      20558522 20558522
      In situ proximity ligation detection of c-Jun/AP-1 dimers reveals increased levels of c-Jun/Fra1 complexes in aggressive breast cancer cell lines in vitro and in vivo.
      Baan, B; Pardali, E; ten Dijke, P; van Dam, H
      Molecular & cellular proteomics : MCP  9  1982-90  2010

      Show Abstract
      20511396 20511396
      Human papillomavirus type 8 E2 protein unravels JunB/Fra-1 as an activator of the beta4-integrin gene in human keratinocytes.
      Oldak M, Maksym RB, Sperling T, Yaniv M, Smola H, Pfister HJ, Malejczyk J, Smola S
      Journal of virology  84  1376-86  2009

      Show Abstract Full Text Article
      19923172 19923172
      Alterations in AP-1 and AP-1 regulatory genes during HPV-induced carcinogenesis.
      Jillian de Wilde, Johanna De-Castro Arce, Peter J F Snijders, Chris J L M Meijer, Frank Rösl, Renske D M Steenbergen, Jillian de Wilde, Johanna De-Castro Arce, Peter J F Snijders, Chris J L M Meijer, Frank Rösl, Renske D M Steenbergen
      Cellular oncology : the official journal of the International Society for Cellular Oncology  30  77-87  2008

      Show Abstract
      18219112 18219112
      Loss of net as repressor leads to constitutive increased c-fos transcription in cervical cancer cells.
      van Riggelen, J; Buchwalter, G; Soto, U; De-Castro Arce, J; zur Hausen, H; Wasylyk, B; Rösl, F
      The Journal of biological chemistry  280  3286-94  2005

      Show Abstract
      15548518 15548518
      c-Fos degradation by the ubiquitin-proteasome proteolytic pathway in osteoclast progenitors.
      Yuji Ito, Daisuke Inoue, Shinsuke Kido, Toshio Matsumoto
      Bone  37  842-9  2005

      Show Abstract
      16172035 16172035
      Induction of ATF3 by ionizing radiation is mediated via a signaling pathway that includes ATM, Nibrin1, stress-induced MAPkinases and ATF-2.
      Kool, J; Hamdi, M; Cornelissen-Steijger, P; van der Eb, AJ; Terleth, C; van Dam, H
      Oncogene  22  4235-42  2003

      Show Abstract
      12833146 12833146
      cDNA array identification of genes regulated in rat renal medulla in response to vasopressin infusion.
      Heddwen L Brooks, Shana Ageloff, Tae-Hwan Kwon, William Brandt, James M Terris, Akhil Seth, Luis Michea, Soren Nielsen, Robert Fenton, Mark A Knepper, Heddwen L Brooks, Shana Ageloff, Tae-Hwan Kwon, William Brandt, James M Terris, Akhil Seth, Luis Michea, Soren Nielsen, Robert Fenton, Mark A Knepper
      American journal of physiology. Renal physiology  284  F218-28  2003

      Show Abstract
      12388413 12388413
      Ten ERK-related proteins in three distinct classes associate with AP-1 proteins and/or AP-1 DNA
      Kumar, N. V. and Bernstein, L. R.
      J Biol Chem, 276:32362-72 (2001)  2001

      Kinase Assay11431474 11431474
      Role of activating protein-1 and high mobility group-I(Y) protein in the induction of CD44 gene expression by interleukin-1beta in vascular smooth muscle cells
      Foster, L. C., et al
      Faseb J, 14:368-78 (2000)  2000

      Electrophoretic Mobility Shift Assay10657993 10657993

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      Included Positive Control

      Catalogue Number Description  
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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies