04-353 | Anti-Fyn Antibody, rabbit monoclonal

04-353
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RIF, IH(P), WBRbPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-353
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Fyn Antibody, rabbit monoclonal
      Alternate Names
      • SLK
      • SYN
      References
      Product Information
      FormatPurified
      Presentation100 μL of rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 90 mM NaCl, 0.006% sodium azide, 0.03% BSA and 40% glycerol.
      Applications
      ApplicationAnti-Fyn Antibody, Rabbit detects level of Fyn & has been published & validated for use in IF, IH(P) & WB.
      Key Applications
      • Immunofluorescence
      • Immunohistochemistry (Paraffin)
      • Western Blotting
      Application NotesSuggested Dilutions:
      Immunoblot Analysis: 1:2000
      Immunofluorescence: 1:50 - 1:100
      Immunohistochemistry: 1:50 - 1:100
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide corresponding to residues near the N-term of human p59 Fyn.
      HostRabbit
      SpecificityRecognizes p59 Fyn.
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.
      Gene Symbol
      • FYN
      • SLK
      • MGC45350
      • SYN
      • p59-Fyn
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P06241 # Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC.
      COFACTOR: Manganese.
      SIZE: 537 amino acids; 60762 Da
      SUBUNIT: Associates through its SH3 domain, to the p85 subunit of phosphatidylinositol 3-kinase. Interacts with the FYN-binding protein (FYB). Interacts with phosphorylated TOM1L1. Interacts with CD79A upon activation of the B-cell antigen receptor which increases FYN activity (By similarity). Interacts with PAG1.
      SUBCELLULAR LOCATION: Cell membrane. Note=Present and active in lipid rafts. Present in cell body and along the process of mature and developing oligodendroyctes.
      TISSUE SPECIFICITY: Isoform 1 is highly expressed in the brain, isoform 2 is expressed in cells of hemopoietic lineages, especially T lymphocytes.
      SIMILARITY: SwissProt: P06241 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
      Molecular Weight59 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment.
      Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Fyn - DAM1409190 DAM1409190
      Anti-Fyn - DAM1514043 DAM1514043
      Anti-Fyn - DAM1614946 DAM1614946
      Anti-Fyn - DAM1644593 DAM1644593
      Anti-Fyn - DAM1764512 DAM1764512
      Anti-Fyn - DAM1785873 DAM1785873
      Anti-Fyn - NG1811093 NG1811093
      Anti-Fyn - NG1853923 NG1853923
      Anti-Fyn, Rabbit Monoclonal - DAM1408856 DAM1408856
      Anti-Fyn, Rabbit Monoclonal - JBC1356730 JBC1356730

      References

      Reference overviewPub Med ID
      Histopathological substrate for chronic atrial fibrillation in humans.
      Nguyen, BL; Fishbein, MC; Chen, LS; Chen, PS; Masroor, S
      Heart rhythm : the official journal of the Heart Rhythm Society  6  454-60  2009

      Show Abstract Full Text Article
      19324302 19324302
      Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP
      Liu, Hui, et al
      J Biol Chem, 281:23611-9 (2006)  2006

      16777849 16777849
      Structure of human Fyn kinase domain complexed with staurosporine
      Kinoshita, Takayoshi, et al
      Biochem Biophys Res Commun, 346:840-4 (2006)  2006

      16782058 16782058
      Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN
      Lowenberg, Mark, et al
      EMBO Rep, 7:1023-9 (2006)  2006

      16888650 16888650
      P59(fyn) is upregulated in anergic CD8+ T cells
      Welke, Judith and Zavazava, Nicholas
      Hum Immunol, 63:834-43 (2002)  2002

      12368035 12368035

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies