06-238 | Anti-Gβ Antibody

50 µL  
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      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MIP, WBRbSerumPolyclonal Antibody
      Catalogue Number06-238
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Gβ Antibody
      Product Information
      PresentationPBS, pH 7.2
      ApplicationDetect Gβ using this Anti-Gβ Antibody validated for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenInternal sequence of G-protein β subunit (KTREGNVRVSREL) conjugated to octavalent polylysine base
      SpecificityGβ subunits; recognizes both isoforms
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryHeterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR.
      Gene Symbol
      • GNB2
      • SG
      • IG
      Purification MethodAntiserum
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P62879 # Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.
      SIZE: 340 amino acids; 37331 Da
      SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma.
      SIMILARITY: SwissProt: P62879 ## Belongs to the WD repeat G protein beta family. & Contains 7 WD repeats.
      Molecular Weight35/36kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceImmunoblot Analysis: A 1:500-1:1000 dilution of this antibody detected the Gβ subunits in 20 μg of a cell lysate prepared from rat brain microsomal preparation (Catalog # 12-144).

      Immunoprecipitation/Immunoblot: 10 μl of this antibody immunoprecipitated the Gβ subunit from 500 μg-1mg of a lysate of rat brain microsomal preparation (Catalog # 12-144).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Gb -2703673 2703673
      Anti-Gbeta - DAM1394785 DAM1394785
      Anti-Gbeta; - 16509 16509
      Anti-Gbeta; - 23547 23547
      Anti-Gbeta; - 32197 32197
      Anti-Gβ 2479781
      Anti-Gβ (rabbit polyclonal IgG) - 3035157 3035157
      Anti-Gβ -2511676 2511676
      Anti-Gβ -2574848 2574848
      Anti-Gβ -2608396 2608396


      Reference overviewApplicationPub Med ID
      Activation of p38 mitogen-activated protein kinase (p38 MAPK), extracellular signal-regulated kinase (ERK) and c-jun N-terminal kinase (JNK) during hypoxia in cerebral cortical nuclei of guinea pig fetus at term: role of nitric oxide.
      Dev Maulik, Qazi M Ashraf, Om P Mishra, Maria Delivoria-Papadopoulos
      Neuroscience letters  439  94-9  2008

      Show Abstract
      18511197 18511197
      Parallel regulation of mitogen-activated protein kinase kinase 3 (MKK3) and MKK6 in Gq-signaling cascade.
      Yamauchi, J; Tsujimoto, G; Kaziro, Y; Itoh, H
      The Journal of biological chemistry  276  23362-72  2001

      Show Abstract
      11304531 11304531
      Differential regulation of mitogen-activated protein kinase kinase 4 (MKK4) and 7 (MKK7) by signaling from G protein beta gamma subunit in human embryonal kidney 293 cells.
      J Yamauchi, Y Kaziro, H Itoh
      The Journal of biological chemistry  274  1957-65  1999

      Show Abstract
      9890951 9890951
      Importance of the G protein gamma subunit in activating G protein-coupled inward rectifier K(+) channels.
      T Kawano, L Chen, S Y Watanabe, J Yamauchi, Y Kaziro, Y Nakajima, S Nakajima, H Itoh
      FEBS letters  463  355-9  1999

      Show Abstract
      10606753 10606753
      Regulated exocytosis in chromaffin cells. A potential role for a secretory granule-associated ARF6 protein
      Galas, M. C., et al
      J Biol Chem, 272:2788-93 (1997)  1997

      Immunoblotting (Western)9006918 9006918
      Insulin-induced activation of NADPH-dependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2
      Krieger-Brauer, H. I., et al
      J Biol Chem, 272:10135-43 (1997)  1997

      Immunoblotting (Western)9092559 9092559
      Possible involvement of heterotrimeric G proteins in the organization of the Golgi apparatus
      Yamaguchi, T., et al
      J Biol Chem, 272:25260-6 (1997)  1997

      Immunocytochemistry9312142 9312142
      C-terminal mutation of G protein beta subunit affects differentially extracellular signal-regulated kinase and c-Jun N-terminal kinase pathways in human embryonal kidney 293 cells.
      J Yamauchi, Y Kaziro, H Itoh, J Yamauchi, Y Kaziro, H Itoh
      The Journal of biological chemistry  272  7602-7  1997

      Show Abstract
      Immunoprecipitation9065414 9065414
      Activation of p38 mitogen-activated protein kinase by signaling through G protein-coupled receptors. Involvement of Gbetagamma and Galphaq/11 subunits.
      J Yamauchi, M Nagao, Y Kaziro, H Itoh
      The Journal of biological chemistry  272  27771-7  1997

      Show Abstract
      9346921 9346921