05-555 | Anti-Giα1 Antibody, clone 7H7

05-555
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      VrtWBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-555
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Giα1 Antibody, clone 7H7
      References
      Product Information
      FormatPurified
      Presentation0.07M Tris-glycine, pH 7.4, 0.105M NaCl, containing 30% glycerol
      Applications
      ApplicationAnti-Giα1 Antibody, clone 7H7 detects level of Giα1 & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenPeptide corresponding to residues 110-123 of Giα1
      Clone7H7
      HostMouse
      SpecificityGiα1
      IsotypeIgG2b
      Species Reactivity
      • Vertebrates
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryGuanine nucleotide-binding proteins (G proteins) form a large family of signal-transducing molecules. They are found as heterotrimers made up of alpha, beta, and gamma subunits. Members of the G protein family have been characterized most extensively on the basis of the alpha subunit, which binds guanine nucleotide, is capable of hydrolyzing GTP, and interacts with specific receptor and effector molecules. The G protein family includes Gs (MIM 139320) and Gi, the stimulatory and inhibitory GTP-binding regulators of adenylate cyclase; Go, a protein abundant in brain (GNAO1; MIM 139311); and transducin-1 (GNAT1; MIM 139330) and transducin-2 (GNAT2; MIM 139340), proteins involved in phototransduction in retinal rods and cones, respectively (Sullivan et al., 1986 [PubMed 3092218]; Bray et al., 1987 [PubMed 3110783]). Suki et al. (1987) [PubMed 2440724] concluded that the human genome contains at least 3 nonallelic genes for alpha-i-type subunits of G protein; see, e.g, GNAI2 (MIM 139360), GNAI3 (MIM 139370), and GNAIH (MIM 139180).[supplied by OMIM]
      Gene Symbol
      • GNAI1
      • Gi
      Purification MethodProtein G Chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P63096 # Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli.
      SIZE: 354 amino acids; 40361 Da
      SUBUNIT: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with GPSM1 (By similarity).
      SIMILARITY: SwissProt: P63096 ## Belongs to the G-alpha family. G(i/o/t/z) subfamily.
      Molecular Weight41kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on rat brain microsomal preparation
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Gia1, clone 7H7 (mouse monoclonal IgG2b) - DAM1437258 DAM1437258
      Anti-Gialpha;1, clone 7H7 - 19480 19480
      Anti-Giα1, clone 7H7 -2514883 2514883
      Anti-Giα1, clone 7H7 -2609836 2609836

      References

      Reference overviewPub Med ID
      Effect of microbubble and its generation process on mixed liquor properties of activated sludge using Shirasu porous glass (SPG) membrane system.
      Chun Liu,Hiroshi Tanaka,Jin Ma,Lei Zhang,Jing Zhang,Xia Huang,Yoshiaki Matsuzawa
      Water research  46  2012

      Show Abstract
      22975738 22975738
      Identification and quantification of Gi-type GTP-binding proteins that copurify with a pituitary somatostatin receptor.
      Luthin, D R, et al.
      J. Biol. Chem., 268: 5990-6 (1993)  1993

      Show Abstract
      8449959 8449959

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies