CBL242 | Anti-Glucose Transporter GLUT-1 Antibody, CT

CBL242
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RIP, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberCBL242
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Glucose Transporter GLUT-1 Antibody, CT
      References
      Product Information
      FormatAffinity Purified
      Control
      • Colorectal carcinoma
      PresentationThe polyclonal is presented in phosphate buffered saline containing 10mM sodium azide. We recommend that each laboratory determine an optimum working titre for use in its particular application.
      Applications
      ApplicationAnti-Glucose Transporter GLUT-1 Antibody, C-terminus detects level of Glucose Transporter GLUT-1 & has been published & validated for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Application NotesWestern blot analysis of GLUT-1 activity in adipose and muscle tissue (5μg/ml)

      Immunoprecipitation of GLUT-1 (5μg/ml)

      Optimal working dilutions must be determined by the end user.
      Biological Information
      Immunogen12 amino acid peptide of the C-terminus of hGLUT-1 {LFHPLGADSQV} conjugated to KLH
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificitySpecific for human glucose transporter 1 from muscle and adipose tissue. Does not cross-react with GLUT-4. The molecular weight of the glucose transporter precipitated by the serum is approximately 46 kDa.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryGlucose transporters are integral membrane glycoproteins involved in transporting glucose into most cells. GLUT1 is a major glucose transporter in the mammalian blood-brain barrier. It is present at high levels in primate erythrocytes and brain endothelial cells.[supplied by OMIM]
      Gene Symbol
      • SLC2A1
      • GLUT-1
      • MGC141896
      • GLUT1
      • MGC141895
      • GLUT
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P11166 # Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.
      SIZE: 492 amino acids; 54084 Da
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Melanosome. Note=Localizes primarily at the cell surface (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
      TISSUE SPECIFICITY: Expressed at variable levels in many human tissues.
      PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
      DISEASE: SwissProt: P11166 # Defects in SLC2A1 are the cause of autosomal dominant GLUT1 deficiency syndrome [MIM:606777]. This disease causes a defect in glucose transport across the blood-brain barrier. It is characterized by infantile seizures, delayed development, and acquired microcephaly.
      SIMILARITY: SwissProt: P11166 ## Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
      Molecular Weight46 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsFor use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C for up to one year.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-HUMAN INSULIN REGULATABLE GLUCOSE TRANSPORTER 1 (GLUT-1) POLYCLONAL ANTISERA 2922481
      RABBIT ANTI-HUMAN INSULIN REGULATABLE GLUCOSE TRANSPORTER 1 (GLUT-1) POLYCLONAL ANTISERA - 2032212 2032212
      RABBIT ANTI-HUMAN INSULIN REGULATABLE GLUCOSE TRANSPORTER 1 (GLUT-1) POLYCLONAL ANTISERA - 2186307 2186307
      RABBIT ANTI-HUMAN INSULIN REGULATABLE GLUCOSE TRANSPORTER 1 (GLUT-1) POLYCLONAL ANTISERA - 2266461 2266461
      RABBIT ANTI-HUMAN INSULIN REGULATABLE GLUCOSE TRANSPORTER 1 (GLUT-1) POLYCLONAL ANTISERA - 2280811 2280811
      RABBIT ANTI-HUMAN INSULIN REGULATABLE GLUCOSE TRANSPORTER 1 (GLUT-1) POLYCLONAL ANTISERA - 2365939 2365939
      RABBIT ANTI-HUMAN INSULIN REGULATABLE GLUCOSE TRANSPORTER 1 - 2493952 2493952
      RABBIT ANTI-HUMAN INSULIN REGULATABLE GLUCOSE TRANSPORTER 1 -2728437 2728437
      RABBIT ANTI-HUMAN INSULIN REGULATABLE GLUCOSE TRANSPORTER 1 -2804219 2804219
      RABBIT ANTI-HUMAN INSULIN REGULATABLE GLUCOSE TRANSPORTER 1 -2812743 2812743

      References

      Reference overviewApplicationPub Med ID
      Rugby-specific small-sided games training is an effective alternative to stationary cycling at reducing clinical risk factors associated with the development of type 2 diabetes: a randomized, controlled trial.
      Mendham, AE; Duffield, R; Coutts, AJ; Marino, F; Boyko, A; Bishop, DJ
      PloS one  10  e0127548  2015

      Show Abstract
      26030423 26030423
      Role of plasma membrane caveolae/lipid rafts in VEGF-induced redox signaling in human leukemia cells.
      Caliceti, C; Zambonin, L; Rizzo, B; Fiorentini, D; Vieceli Dalla Sega, F; Hrelia, S; Prata, C
      BioMed research international  2014  857504  2014

      Show Abstract
      24738074 24738074
      Metformin and male reproduction: effects on Sertoli cell metabolism.
      Alves, MG; Martins, AD; Vaz, CV; Correia, S; Moreira, PI; Oliveira, PF; Socorro, S
      British journal of pharmacology  171  1033-42  2014

      Show Abstract
      24261663 24261663
      Glycolytic switch in response to betulinic acid in non-cancer cells.
      Heiss, EH; Kramer, MP; Atanasov, AG; Beres, H; Schachner, D; Dirsch, VM
      PloS one  9  e115683  2014

      Show Abstract
      25531780 25531780
      γ-secretase binding sites in aged and Alzheimer's disease human cerebrum: the choroid plexus as a putative origin of CSF Aβ.
      Liu, F; Xue, ZQ; Deng, SH; Kun, X; Luo, XG; Patrylo, PR; Rose, GM; Cai, H; Struble, RG; Cai, Y; Yan, XX
      The European journal of neuroscience  37  1714-25  2013

      Show Abstract
      23432732 23432732
      Androgen-responsive and nonresponsive prostate cancer cells present a distinct glycolytic metabolism profile.
      C Vaz,Marco G Alves,Ricardo Marques,Paula I Moreira,Pedro F Oliveira,Cl Maia,S Socorro
      The international journal of biochemistry & cell biology  44  2012

      Show Abstract
      22964025 22964025
      Effect of plasma membrane cholesterol depletion on glucose transport regulation in leukemia cells.
      Caliceti, C; Zambonin, L; Prata, C; Vieceli Dalla Sega, F; Hakim, G; Hrelia, S; Fiorentini, D
      PloS one  7  e41246  2012

      Show Abstract
      22859971 22859971
      TBC1D1 regulates insulin- and contraction-induced glucose transport in mouse skeletal muscle.
      An, D; Toyoda, T; Taylor, EB; Yu, H; Fujii, N; Hirshman, MF; Goodyear, LJ
      Diabetes  59  1358-65  2010

      Show Abstract Full Text Article
      Western Blotting, Immunoprecipitation20299473 20299473
      Rapid upregulation of GLUT-4 and MCT-4 expression during 16 h of heavy intermittent cycle exercise.
      Green, HJ; Duhamel, TA; Holloway, GP; Moule, JW; Ranney, DW; Tupling, AR; Ouyang, J
      American journal of physiology. Regulatory, integrative and comparative physiology  294  R594-600  2008

      Show Abstract
      Western Blotting18056982 18056982
      Altered metabolic and transporter characteristics of vastus lateralis in chronic obstructive pulmonary disease.
      Green, HJ; Burnett, ME; D'Arsigny, CL; O'Donnell, DE; Ouyang, J; Webb, KA
      Journal of applied physiology (Bethesda, Md. : 1985)  105  879-86  2008

      Show Abstract
      18635880 18635880

      Data Sheet

      Title
      RABBIT ANTI-HUMAN INSULIN REGULATABLE GLUCOSE TRANSPORTER 1 (GLUT-1) POLYCLONAL ANTISERA

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies