CBL243 | Anti-Glucose Transporter GLUT-4 Antibody

CBL243
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RIP, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberCBL243
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Glucose Transporter GLUT-4 Antibody
      References
      Product Information
      FormatAffinity Purified
      Control
      • Positive Control: 3T3 L1 adipocyte membranes
      PresentationPurified immunoglobulin in PBS with 0.01% sodium azide.
      Applications
      ApplicationThis Anti-Glucose Transporter GLUT-4 Antibody is validated for use in IP, WB for the detection of Glucose Transporter GLUT-4.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Application NotesWestern blot analysis of GLUT-4 activity in adipose and muscle tissue (5μg/ml)

      Immunoprecipitation of GLUT-4 (5μg/ml)

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenPartially purified GLUT-4
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificitySpecific for human glucose transporter-4 from muscle and adipose tissue. The antisera does not cross-react with GLUT-1. The molecular weight of the glucose transporter precipitated by the serum is approximately 46 kDa.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM).
      Gene Symbol
      • SLC2A4
      • GLUT-4
      • GLUT4
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P14672 # Insulin-regulated facilitative glucose transporter.
      SIZE: 509 amino acids; 54787 Da
      SUBUNIT: Binds to DAXX.
      SUBCELLULAR LOCATION: Intracytoplasmic membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization motif is critical for intracellular sequestration.
      TISSUE SPECIFICITY: Skeletal and cardiac muscles; brown and white fat.
      PTM: Sumoylated.
      DISEASE: SwissProt: P14672 # Defects in SLC2A4 may be a cause of noninsulin-dependent diabetes mellitus (NIDDM) [MIM:125853]. Defects in SLC2A4 may be a cause of certain post-receptor defects in NIDDM. The variant in position Ile-383 is found in a small number of NIDDM patients, but seems not to be found in nondiabetic subjects.
      SIMILARITY: SwissProt: P14672 ## Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
      MISCELLANEOUS: Insulin-stimulated phosphorylation of TBC1D4 is required for GLUT4 translocation (By similarity).
      Molecular Weight46 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsFor use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RABBIT ANTI- INSULIN REGULATABLE GLUCOSE -2805379 2805379
      RABBIT ANTI- INSULIN REGULATABLE GLUCOSE TRANSPORTER 4 (GLUT-4) POLYCLONAL ANTISERA 2908072
      RABBIT ANTI- INSULIN REGULATABLE GLUCOSE TRANSPORTER 4 (GLUT-4) POLYCLONAL ANTISERA - 2430362 2430362
      RABBIT ANTI- INSULIN REGULATABLE GLUCOSE TRANSPORTER 4 (GLUT-4) POLYCLONAL ANTISERA - 2032213 2032213
      RABBIT ANTI- INSULIN REGULATABLE GLUCOSE TRANSPORTER 4 (GLUT-4) POLYCLONAL ANTISERA - 2121743 2121743
      RABBIT ANTI- INSULIN REGULATABLE GLUCOSE TRANSPORTER 4 (GLUT-4) POLYCLONAL ANTISERA - 2196003 2196003
      RABBIT ANTI- INSULIN REGULATABLE GLUCOSE TRANSPORTER 4 (GLUT-4) POLYCLONAL ANTISERA - 2290940 2290940
      RABBIT ANTI- INSULIN REGULATABLE GLUCOSE TRANSPORTER 4 (GLUT-4) POLYCLONAL ANTISERA -2506319 2506319
      RABBIT ANTI- INSULIN REGULATABLE GLUCOSE TRANSPORTER 4 (GLUT-4) POLYCLONAL ANTISERA -2689125 2689125
      RABBIT ANTI- INSULIN REGULATABLE GLUCOSE TRANSPORTER 4 (GLUT-4) POLYCLONAL ANTISERA -2716612 2716612

      References

      Reference overviewApplicationPub Med ID
      Methotrexate Increases Skeletal Muscle GLUT4 Expression and Improves Metabolic Control in Experimental Diabetes.
      Russo, GT; Minutoli, L; Bitto, A; Altavilla, D; Alessi, E; Giandalia, A; Romeo, EL; Stagno, MF; Squadrito, F; Cucinotta, D; Selhub, J
      Journal of nutrition and metabolism  2012  132056  2012

      Show Abstract
      22778921 22778921
      The Rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism.
      Szekeres, F; Chadt, A; Tom, RZ; Deshmukh, AS; Chibalin, AV; Björnholm, M; Al-Hasani, H; Zierath, JR
      American journal of physiology. Endocrinology and metabolism  303  E524-33  2012

      Show Abstract
      Western Blotting22693207 22693207
      Preventing the calorie restriction-induced increase in insulin-stimulated Akt2 phosphorylation eliminates calorie restriction's effect on glucose uptake in skeletal muscle.
      Sharma, N; Arias, EB; Sequea, DA; Cartee, GD
      Biochimica et biophysica acta  1822  1735-40  2012

      Show Abstract
      22846604 22846604
      Rapid upregulation of GLUT-4 and MCT-4 expression during 16 h of heavy intermittent cycle exercise.
      Green, HJ; Duhamel, TA; Holloway, GP; Moule, JW; Ranney, DW; Tupling, AR; Ouyang, J
      American journal of physiology. Regulatory, integrative and comparative physiology  294  R594-600  2008

      Show Abstract
      Western Blotting18056982 18056982

      Data Sheet

      Title
      RABBIT ANTI- INSULIN REGULATABLE GLUCOSE TRANSPORTER 4 (GLUT-4) POLYCLONAL ANTISERA

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies