05-1420 | Anti-Grb14 Antibody, clone 24

05-1420
100 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Click To Print This Page

      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, H, MWBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-1420
      DescriptionAnti-Grb14 Antibody, clone 24
      Alternate Names
      • GRB14 adapter protein
      • growth factor receptor-bound protein 14
      Background InformationGrb14 is a 58 kDa protein that interacts in vivo with both the insulin receptor (IR) and Fibroblast Growth Factor Receptor 1 (FGFR1). The function of Grb14 is poorly understood, but overexpression of Grb14 suppresses insulin-induced DNA and glycogen synthesis, suggesting that it may be a modulator of IR signaling.
      References
      Product Information
      FormatPurified
      Control
      • NIH/3T3 cell lysates
      PresentationPurified Immunoglobulin. Liquid in PBS, pH 7.6 with 0.1% sodium azide
      Applications
      ApplicationAnti-Grb14 Antibody, clone 24 detects level of Grb14 & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenSynthetic peptide corresponding to human Grb14 amino acids 79-229.
      Epitopea.a. 79-229
      Clone24
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody specifically reacts within the Grb14 amino acid sequence 79-229 of the human sequence.
      IsotypeIgG1
      Species Reactivity
      • Rat
      • Human
      • Mouse
      Species Reactivity NoteReacts with human. Expected to react in mouse and rat based on sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Interacts with the cytoplasmic domain of the autophosphorylated insulin receptor which is then inhibited. The interaction is mediated by the SH2 domain By similarity.
      SUBUNIT STRUCTURE: Binds to the ankyrin repeat region of TNKS2 via its N-terminus.
      SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
      TISSUE SPECIFICITY: Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.
      PTM: Phosphorylated on serine residues.
      SEQUENCE SIMILARITIES: Belongs to the GRB7/10/14 family.
      Contains 1 PH domain.
      Contains 1 Ras-associating domain.
      Contains 1 SH2 domain.
      Molecular WeightApprox. 58 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in NIH/3T3 cell lysates.
      Western Blot Analysis: 1:500 dilution of this lot detected Grb14 on 10 ug of NIH/3T3 lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C in undiluted aliquots for up to 1 year from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications