07-1548 | Anti-HDAC11 Antibody

07-1548
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, ELISA, IHCRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number07-1548
      DescriptionAnti-HDAC11 Antibody
      Alternate Names
      • histone deacetylase 11
      Background InformationHDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation is a marker for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.
      References
      Product Information
      FormatPurified
      Control
      • Mouse Brain cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.09% NaN3.
      Applications
      ApplicationUse Anti-HDAC11 Antibody (Rabbit Polyclonal Antibody) validated in WB, ELISA, IHC to detect HDAC11 also known as histone deacetylase 11.
      Key Applications
      • Western Blotting
      • ELISA
      • Immunohistochemistry
      Application NotesELISA:
      This antibody has been shown by an outside laboratory to be suitable for ELISA (1:1000).

      Immunohistochemistry:
      This antibody has been shown by an outside laboratory to be suitable for histochemistry using formalin fixed, paraffin embedded human hepatocarcinoma tissue (1:50-1:100).
      Biological Information
      ImmunogenThe immunogen was a KLH-conjugated synthetic peptide corresponding the N-terminal region of human HDAC11.
      EpitopeN-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes HDAC11.
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteHuman, Mouse. Not tested in other species.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.

      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Gene Symbol
      • HD11
      • FLJ22237
      • EC 3.5.1.98
      Purification MethodProtein G Chromatography
      UniProt Number
      UniProt SummaryFUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Ref.4

      Catalytic activity Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

      SUBUNIT STRUCTURE: Interacts with HDAC6. Ref.4

      SUBCELLULAR LOCATION: Nucleus. Note= Predominantly nuclear.

      TISSUE SPECIFICITY: Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis.

      MISCELLANEOUS: Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.

      SEQUENCE SIMILARITY: Belongs to the histone deacetylase family.

      SEQUENCE CAUTION:The sequence BAB15127.1 differs from that shown. Reason: Erroneous termination at position 107. Translated as Gln.

      The sequence CAB70712.1 differs from that shown. Reason: Frameshift at positions 177, 198 and 200.

      Molecular Weight~40 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceWestern Blot Analysis:
      Detection of HDAC11 in 10 µg of Mouse Brain lysate by Western blot analysis.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 6 months at 2-8°C from date of receipt. For long term storage, store at -20ºC. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications