09-827 | Anti-HDAC11 Antibody

09-827
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number09-827
      DescriptionAnti-HDAC11 Antibody
      Alternate Names
      • histone deacetylase 11
      Background InformationHDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation is a marker for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Human brain tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Applications
      ApplicationAnti-HDAC11 Antibody is a Rabbit Polyclonal Antibody for detection of HDAC11 also known as histone deacetylase 11 & has been validated in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern Blot (SNAP ID) Analysis: 0.5 µg/ml from a representative lot detected HDAC11 on 10 µg of human brain tissue lysate.

      Biological Information
      ImmunogenLinear Peptide corresponding to human HDAC11 at amino acids 228-246.
      EpitopeAmino Acid: 228-246
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes HDAC11.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene Summary This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.
      Gene Symbol
      • HDAC11
      • HD11
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.

      CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

      SUBUNIT STRUCTURE: Interacts with HDAC6.

      SUBCELLULAR LOCATION: Nucleus. Note: Predominantly nuclear.

      TISSUE SPECIFICTY: Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis.

      MISCELLANEOUS: Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.

      SEQUENCE SIMILARITIES: Belongs to the histone deacetylase family.

      SEQUENCE CAUTION: The sequence BAB15127.1 differs from that shown. Reason: Erroneous termination at position 107. Translated as Gln.

      The sequence CAB70712.1 differs from that shown. Reason: Frameshift at positions 177, 198 and 200.
      Molecular Weight39 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human brain tissue lysate.

      Western Blot Analysis: 0.05 µg/ml of this antibody detected HDAC11 on 10 µg of human brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications