06-890 | Anti-HDAC3 Antibody

06-890
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-890
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-HDAC3 Antibody
      References
      Product Information
      FormatPurified
      Presentationof 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
      Applications
      ApplicationAnti-HDAC3 Antibody is a Rabbit Polyclonal Antibody for detection of HDAC3 also known as histone deacetylase 3 & has been tested in WB.
      Key Applications
      • Western Blotting
      Biological Information
      Immunogenpeptide corresponding to amino acids 411-428 of human HDAC3 (NEFYDGDHDNDKESDVEI)
      HostRabbit
      SpecificityHDAC3
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryHistones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
      Gene Symbol
      • HDAC3
      • SMAP45
      • HD3
      • RPD3
      • RPD3-2
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O15379 # Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor.
      SIZE: 428 amino acids; 48848 Da
      SUBUNIT: Interacts with HDAC7 and HDAC9. Forms a heterologous complex at least with YY1. Interacts with DAXX, HDAC10 and DACH1. Found in a complex with NCOR1 and NCOR2. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with BCOR, MJD2A/JHDM3A, NRIP1 and SRY. Interacts with BTBD14B. Interacts with GLIS2 (By similarity). Interacts with CBFA2T3.
      SUBCELLULAR LOCATION: Nucleus.
      TISSUE SPECIFICITY: Widely expressed.
      PTM: Sumoylated in vitro.
      SIMILARITY: SwissProt: O15379 ## Belongs to the histone deacetylase family. Type 1 subfamily.
      Molecular Weight49kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on a HeLa RIPA cell lysate
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-HDAC3 (rabbit polyclonal IgG) - 2360660 2360660
      Anti-HDAC3 - 18869 18869
      Anti-HDAC3 - 21853 21853
      Anti-HDAC3 - 23665 23665
      Anti-HDAC3 - 29558 29558

      References

      Reference overviewApplicationSpeciesPub Med ID
      Histone deacetylase 3 is required for maintenance of bone mass during aging.
      McGee-Lawrence, ME; Bradley, EW; Dudakovic, A; Carlson, SW; Ryan, ZC; Kumar, R; Dadsetan, M; Yaszemski, MJ; Chen, Q; An, KN; Westendorf, JJ
      Bone  52  296-307  2013

      Show Abstract
      23085085 23085085
      Recruitment of a SAP18-HDAC1 complex into HIV-1 virions and its requirement for viral replication.
      Sorin, M; Cano, J; Das, S; Mathew, S; Wu, X; Davies, KP; Shi, X; Cheng, SW; Ott, D; Kalpana, GV
      PLoS pathogens  5  e1000463  2009

      Show Abstract
      19503603 19503603
      Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1.
      Romeo, GR; Kazlauskas, A
      The Journal of biological chemistry  283  9595-605  2008

      Show Abstract
      Western BlottingRat18230613 18230613
      JDP2 suppresses adipocyte differentiation by regulating histone acetylation.
      Nakade, K; Pan, J; Yoshiki, A; Ugai, H; Kimura, M; Liu, B; Li, H; Obata, Y; Iwama, M; Itohara, S; Murata, T; Yokoyama, KK
      Cell death and differentiation  14  1398-405  2007

      Show Abstract
      17464331 17464331
      Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease.
      Bilodeau, S; Vallette-Kasic, S; Gauthier, Y; Figarella-Branger, D; Brue, T; Berthelet, F; Lacroix, A; Batista, D; Stratakis, C; Hanson, J; Meij, B; Drouin, J
      Genes & development  20  2871-86  2006

      Show Abstract
      17043312 17043312
      Histone deacetylase inhibitors differentially stabilize acetylated p53 and induce cell cycle arrest or apoptosis in prostate cancer cells.
      Roy, S; Packman, K; Jeffrey, R; Tenniswood, M
      Cell death and differentiation  12  482-91  2005

      Show Abstract
      15746940 15746940
      Class I histone deacetylase-selective novel synthetic inhibitors potently inhibit human tumor proliferation.
      Park, JH; Jung, Y; Kim, TY; Kim, SG; Jong, HS; Lee, JW; Kim, DK; Lee, JS; Kim, NK; Kim, TY; Bang, YJ
      Clinical cancer research : an official journal of the American Association for Cancer Research  10  5271-81  2004

      Show Abstract
      15297431 15297431
      Specific targeting and constitutive association of histone deacetylase complexes during transcriptional repression
      Li, J., et al
      Genes Dev, 16:687-92 (2002)  2002

      Chromatin Immunoprecipitation (ChIP)11914274 11914274
      Histone acetylation and transcriptional regulatory mechanisms.
      Struhl, K
      Genes Dev., 12: 599-606 (1998)  1998

      9499396 9499396
      Cloning and characterization of the mouse histone deacetylase-2 gene.
      Zeng, Y, et al.
      J. Biol. Chem., 273: 28921-30 (1998)  1998

      Show Abstract
      9786895 9786895

      Technical Info

      Title
      White Paper - The Message in the Marks: Deciphering Cancer Epigenetics

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      Life Science Research > Antibodies and Assays > Primary Antibodies