04-348 | Anti-HER4/ErbB4 Antibody, clone E200, rabbit monoclonal

04-348
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, ICC, IP, FCRbUnpurifiedMonoclonal Antibody
      Description
      Catalogue Number04-348
      DescriptionAnti-HER4/ErbB4 Antibody, clone E200, rabbit monoclonal
      Alternate Names
      • v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
      • Proto-oncogene-like protein c-ErbB-4
      • Tyrosine kinase-type cell surface receptor HER4
      • v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4
      • avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4
      • receptor tyrosine-protein kinase erbB-4
      Background InformationHER4 / ErbB4 is a receptor tyrosine kinase that belongs to the human epidermal growth factor receptor (EGFR) family. ErbB4/HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum (1). ErbB4/HER4 is activated by neuregulins (NRG), betacellulin (BTC), and heparin-binding EGF-like growth factor (2). Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of ErbB 1-4. The ErbB4/HER4 receptor is unique among these receptors because its C-terminal tail binds to a protein motif known as the PDZ domain (3).
      References
      Product Information
      FormatUnpurified
      Control
      • MCF-7 cell lysate
      PresentationRabbit Monoclonal in buffer containing glycerol, BSA, and sodium azide.
      Applications
      ApplicationPlease note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Immunoprecipitation
      • Flow Cytometry
      Application NotesImmunocytochemistry Analysis: A 1:50 dilution from a representative lot was used in IC.
      Immunoprecipitation Analysis: A 1:100 dilution from a representative lot was used in IP.
      Flow Cytometry Analysis: A 1:40 dilution from a representative lot was used in FC.
      Biological Information
      ImmunogenSynthetic peptide corresponding to the C-terminus of human HER4/ErbB4. The antibody does not cross-react with other EGF receptor family members.
      EpitopeC-terminus
      CloneE200
      HostRabbit
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • HER4
      • p180erbB4
      • EC 2.7.10.1
      • MGC138404
      • OTTHUMP00000163968
      • OTTHUMP00000206623
      • OTTHUMP00000209432
      • EC 2.7.10
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~185 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in MCF-7 cell lysate.
      Western Blot Analysis: A 1:4,000 dilution of this antibody detected HER4/ErbB4 in MCF-7 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20ºC from date of receipt.
      Handling Recommendations: Upon first thaw, and prior to removing cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20ºC. Avoid freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-HER4/ErbB4, clone E200, Rabbit Monoclonal 2487602
      Anti-HER4/ErbB4, clone E200, Rabbit Monoclonal - 2367764 2367764
      Anti-HER4/ErbB4, clone E200, Rabbit Monoclonal - 2424097 2424097
      Anti-HER4/ErbB4, clone E200, Rabbit Monoclonal - 2435047 2435047
      Anti-HER4/ErbB4, clone E200, Rabbit Monoclonal - 2466258 2466258
      Anti-HER4/ErbB4, clone E200, Rabbit Monoclonal - 2190474 2190474
      Anti-HER4/ErbB4, clone E200, Rabbit Monoclonal - 2251778 2251778
      Anti-HER4/ErbB4, clone E200, Rabbit Monoclonal - Q1996112 Q1996112
      Anti-HER4/ErbB4, clone E200, Rabbit Monoclonal -2521576 2521576

      Brochure

      Title
      New Products: Volume 3, 2012

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies