09-084 | Anti-HLX1 Antibody

09-084
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number09-084
      DescriptionAnti-HLX1 Antibody
      Alternate Names
      • H2.0 (Drosophila)-like homeo box 1
      • H2.0-like homeo box 1
      • H2.0-like homeo box-1
      • H2.0-like homeobox
      • H2.0-like homeobox 1
      • H2.0-like homeobox 1 (Drosophila)
      • Homeobox protein HB24
      • Homeobox protein HLX1
      Background InformationHLX1 homeobox protein (H2.0-like homeobox protein) is a transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. HLX1 is involved in embryogenesis and hematopoiesis and is located in the nucleus. HLX1 can be found at low levels in normal B and T-cells, and at high levels in activated lymphocytes and monocytes. HLX1 can also found in thymus, tonsil, bone marrow, developing vessels, and fetal brain tissue.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Raji cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-HLX1 Antibody is a Rabbit Polyclonal Antibody for detection of HLX1 also known as H2.0 (Drosophila)-like homeo box 1, Homeobox protein HLX1 & has been validated in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern Blot (SNAP ID) Analysis: 2 µg/mL from a previous lot detected HLX1 in Western Blot (SNAP ID) Analysis.
      Biological Information
      ImmunogenKLH conjugated linear peptide corresponding to human HLX1.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes HLX1.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteDemonstrated to react with human, mouse, and rat. Cow (82% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • HB24
      • HLX1
      • OTTHUMP00000035459
      • homeobox
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis By similarity.
      SUBCELLULAR LOCATION: Nucleus Potential.
      TISSUE SPECIFICITY: Low level in normal B and T-cells, high level in activated lymphocytes and monocytes. Also found in thymus, tonsil, bone marrow, developing vessels, and fetal brain.
      SEQUENCE SIMILARITIES: Belongs to the H2.0 homeobox family.
      Contains 1 homeobox DNA-binding domain.
      SEQUENCE CAUTION: The sequence BAD92049.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
      The sequence BAD92049.1 differs from that shown. Reason: Frameshift at positions 198, 259 and 321.
      The sequence M60721 differs from that shown. Reason: Frameshift at positions 69, 115, 152 and 167.
      Molecular Weight~51 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in raji cell lysate.
      Western Blot Analysis: 0.25 µg/mL of this antibody detected HLX1 in 10 µg of raji cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable at 2-8°C for 1 year from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-HLX1 - 2439204 2439204
      Anti-HLX1 - 2272148 2272148
      Anti-HLX1 - NG1940549 NG1940549
      Anti-HLX1 - NRG1635944 NRG1635944
      Anti-HLX1 -2664285 2664285
      Anti-HLX1 -2712449 2712449
      Anti-HLX1 -2714099 2714099

      References

      Reference overviewPub Med ID
      Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK⁴a regulation.
      Martin, N; Popov, N; Aguilo, F; O'Loghlen, A; Raguz, S; Snijders, AP; Dharmalingam, G; Li, S; Thymiakou, E; Carroll, T; Zeisig, BB; So, CW; Peters, G; Episkopou, V; Walsh, MJ; Gil, J
      The EMBO journal  32  982-95  2013

      Show Abstract
      23455154 23455154

      Technical Info

      Title
      Protein Blotting Handbook: 6th Edition