07-956 | Anti-Hexim 2 Antibody

07-956
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, ChpWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-956
      DescriptionAnti-Hexim 2 Antibody
      Alternate Names
      • Hexamethylene bis-acetamide-inducible protein 2
      • MAQ1 paralog
      • hexamethylene-bis-acetamide-inducible transcript 2
      • hexamthylene bis-acetamide inducible 2
      Background InformationRegulates transcription by acting as a general inhibitor of RNA polymerase II. Similar to HEXIM1, HEXIM2 forms a complex with p-TEFb and 7SK that prevents p-TEFb from activating transcriptional elongation. When HEXIM1 is knocked down, HEXIM2 functionally compensates for its association with P-TEFb. HEXIM2 is up-regulated by HMBA (hexamethylene bisacetamide) at protein level.


      References
      Product Information
      FormatAffinity Purified
      Control
      • HeLa cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Applications
      ApplicationUse Anti-Hexim 2 Antibody (Rabbit Polyclonal Antibody) validated in WB to detect Hexim 2 also known as Hexamethylene bis-acetamide-inducible protein 2, MAQ1 paralog.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Hexim 2 at and around the N-terminus.
      EpitopeN-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes Hexim 2 at the N-terminus.
      Species Reactivity
      • Human
      • Chimpanzee
      Species Reactivity NoteDemonstrated to react with human. Predicted to react with chimpanzee based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • HEXIM2
      • L3
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.

      SUBUNIT STRUCTURE: Homo-oligomer and heterooligomer with HEXIM1; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs.

      SUBCELLULAR LOCATION: Nucleus.

      TISSUE SPECIFICITY: Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed.

      INDUCTION: Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level).

      DOMAIN: The coiled-coil domain mediates oligomerization.

      SEQUENCE SIMILARITIES: Belongs to the HEXIM family.
      Molecular Weight 42 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HeLa cell lysate.

      Western Blot Analysis: 0.1 µg/ml of this antibody detected Hexim 2 on 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies