CBL450F | Anti-ICAM-1 Antibody, clone 15.2, FITC conjugated

CBL450F
100 assays  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFC, IHCMFITCMonoclonal Antibody
      Description
      Catalogue NumberCBL450F
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-ICAM-1 Antibody, clone 15.2, FITC conjugated
      Alternate Names
      • CD54
      References
      Product Information
      FormatFITC
      PresentationThe conjugate is supplied as a liquid in phosphate buffered saline containing 10mM sodium azide and 1 mg/mL bovine serum albumin
      Applications
      ApplicationThis Anti-ICAM-1 Antibody, clone 15.2, FITC conjugated is validated for use in FC, IH for the detection of ICAM-1d.
      Key Applications
      • Flow Cytometry
      • Immunohistochemistry
      Application NotesICAM-1 is a lymphokine inducable molecule and may be used in studies of LFA-1 mediated adhesion

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenRheumatoid synovial cells and fibronectin adherent monocytes
      Clone15.2
      HostMouse
      SpecificityThis antibody recognizes ICAM-1, a 90 kDa integral membrane glycoprotein with seven potential N-linked glycosylation sites. ICAM-1 is the principal ligand of LFA-1. ICAM-1 is a lymphokine inducable molecule and may be used in studies of LFA-1 mediated adhesion. The antigen is expressed on endothelial cells and many other types of cells on activation including lymphocytes and fibroblasts.
      FUSION PARTNER: SP2/0 myeloma cell line
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryICAM1 (CD54) is typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. ICAM1 is also exploited by Rhinovirus as a receptor.
      Gene Symbol
      • ICAM1
      • P3.58
      • BB2
      • CD54
      • ICAM-1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P05362 # ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). In case of rhinovirus infection acts as a cellular receptor for the virus. Also acts as receptor for some coxsackieviruses.
      SIZE: 532 amino acids; 57825 Da
      SUBUNIT: Interacts with human herpesvirus 8 MIR2 protein (Probable).
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      PTM: Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
      SIMILARITY: SwissProt: P05362 ## Belongs to the immunoglobulin superfamily. ICAM family. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at 2-8°C protected from light for uyp to 12 months from date of receipt. DO NOT FREEZE.
      Packaging Information
      Material Size100 assays
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-HUMAN ICAM-1 FITC CONJUGATED MONOCLONAL ANTIBODY - 2421564 2421564
      MOUSE ANTI-HUMAN ICAM-1 -2504872 2504872
      MOUSE ANTI-HUMAN ICAM-1 FITC CONJUGATED MONOCLONAL ANTIBODY - 1997403 1997403
      MOUSE ANTI-HUMAN ICAM-1 FITC CONJUGATED MONOCLONAL ANTIBODY - 2024529 2024529
      MOUSE ANTI-HUMAN ICAM-1 FITC CONJUGATED MONOCLONAL ANTIBODY_ 2826961 2826961

      References

      Reference overviewPub Med ID
      Induction of pro-inflammatory response of the placental trophoblast by Plasmodium falciparum infected erythrocytes and TNF.
      Vásquez, AM; Segura, C; Blair, S
      Malaria journal  12  421  2013

      Show Abstract
      24237643 24237643
      Protein C activation peptide inhibits the expression of ICAM-1, VCAM-1, and interleukin-8 induced by TNF-α in human dermal microvascular endothelial cells.
      Pina-Canseco, Mdel S; Páez-Arenas, A; Massó, F; Pérez-Campos, E; Martínez-Cruz, R; Hernández-Cruz, P; Majluf-Cruz, A; Martínez-Cruz, M; Pérez-Campos Mayoral, L; Pérez-Santiago, AD; Zenteno, E
      Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society  50  407-13  2012

      Show Abstract
      23042271 23042271

      Data Sheet

      Title
      MOUSE ANTI-HUMAN ICAM-1

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies