06-109 | Anti-IGFBP-4 Antibody

06-109
200 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, H, M, PoIP, WBRbSerumPolyclonal Antibody
      Description
      Catalogue Number06-109
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-IGFBP-4 Antibody
      References
      Product Information
      FormatSerum
      Presentationlyophilized
      Applications
      ApplicationAnti-IGFBP-4 Antibody detects level of IGFBP-4 & has been published & validated for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenPurified human IGFBP-4
      HostRabbit
      SpecificityIGFBP-4
      IsotypeIgG
      Species Reactivity
      • Bovine
      • Human
      • Mouse
      • Pig
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
      Gene Symbol
      • IGFBP4
      • IGFBP-5
      • IGFBP-4
      • IBP4
      • HT29-IGFBP
      • BP-4
      Purification MethodAntiserum
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P22692 # IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
      SIZE: 258 amino acids; 27934 Da
      SUBUNIT: Binds IGF2 more than IGF1.
      SUBCELLULAR LOCATION: Secreted.
      SIMILARITY: SwissProt: P22692 ## Contains 1 IGFBP N-terminal domain. & Contains 1 thyroglobulin type-1 domain.
      Molecular Weight24kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on concentrated serum-free T98G culture supernatant
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-IGFBP-4 2477924
      Anti-IGFBP-4 (rabbit antiserum) - 2091902 2091902
      Anti-IGFBP-4 (rabbit antiserum) - 2197501 2197501
      Anti-IGFBP-4 (rabbit antiserum) - 2231280 2231280
      Anti-IGFBP-4 - 13616 13616
      Anti-IGFBP-4 - 16603 16603
      Anti-IGFBP-4 - 19443 19443
      Anti-IGFBP-4 - 33448 33448
      Anti-IGFBP-4 -2794465 2794465

      References

      Reference overviewApplicationPub Med ID
      Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells.
      Severino, V; Alessio, N; Farina, A; Sandomenico, A; Cipollaro, M; Peluso, G; Galderisi, U; Chambery, A
      Cell death & disease  4  e911  2013

      Show Abstract
      24201810 24201810
      Interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor alpha (TNF alpha) regulate insulin-like growth factor binding protein-1 (IGFBP-1) levels and mRNA abundance in vivo and in vitro
      Benbassat, C. A., et al
      Horm Metab Res, 31:209-15 (1999)  1999

      Immunoprecipitation10226804 10226804
      Estradiol increases relative amounts of insulin-like growth factor binding protein (IGFBP)-3 in serum and expression of IGFBP-2 in anterior pituitaries of ewes.
      J A Clapper, J L Snyder, A J Roberts, D L Hamernik, G E Moss
      Biology of reproduction  59  124-30  1998

      Show Abstract
      Immunoprecipitation9675002 9675002
      Identification of the forms of insulin-like growth factor-binding proteins produced by human fibroblasts and the mechanisms that regulate their secretion.
      Camacho-Hubner, C, et al.
      J. Biol. Chem., 267: 11949-56 (1992)  1992

      Show Abstract
      1376315 1376315