07-580 | Anti-IKKε Antibody

07-580
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number07-580
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-IKKε Antibody
      References
      Product Information
      FormatPurified
      Presentationof 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
      Applications
      ApplicationThis Anti-IKKε Antibody is validated for use in WB for the detection of IKKε.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated, synthetic peptide corresponding to amino acids 582-596 (SHLAKRLLQVFQEEC) of human IKKε
      HostRabbit
      SpecificityIKKε
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • IKBKE
      • IKKI
      • MGC125294
      • IKK-i
      • IKKE
      • IKK-epsilon
      • IkBKE
      • MGC125295
      • MGC125297
      • KIAA0151
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q14164 # Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response.
      SIZE: 716 amino acids; 80462 Da
      SUBUNIT: May interact with MAVS/IPS1. Interacts with AZI2. Interacts with SIKE. Interacts with TICAM1/TRIF, IRF3 and DDX58/RIG-I, interactions are disrupted by the interaction between IKBKE and SIKE.
      SUBCELLULAR LOCATION: Cytoplasm (Probable).
      TISSUE SPECIFICITY: Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta. Weakly expressed in lung, kidney, prostate, ovary and colon.
      PTM: Autophosphorylated.
      SIMILARITY: SwissProt: Q14164 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. IkappaB kinase subfamily. & Contains 1 protein kinase domain.
      Molecular WeightMr 80kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 2 years at -20°
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-IKKepsilon; - 26949 26949
      Anti-IKKε -2770045 2770045

      References

      Reference overviewPub Med ID
      Elevated expression of TANK-binding kinase 1 enhances tamoxifen resistance in breast cancer.
      Wei, C; Cao, Y; Yang, X; Zheng, Z; Guan, K; Wang, Q; Tai, Y; Zhang, Y; Ma, S; Cao, Y; Ge, X; Xu, C; Li, J; Yan, H; Ling, Y; Song, T; Zhu, L; Zhang, B; Xu, Q; Hu, C; Bian, XW; He, X; Zhong, H
      Proceedings of the National Academy of Sciences of the United States of America  111  E601-10  2014

      Show Abstract
      24449872 24449872
      IKKi/IKKepsilon plays a key role in integrating signals induced by pro-inflammatory stimuli.
      Kravchenko, Vladimir V, et al.
      J. Biol. Chem., 278: 26612-9 (2003)  2003

      Show Abstract
      12736252 12736252

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies