04-462 | Anti-IL-1 β Antibody, rabbit monoclonal

04-462
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-462
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-IL-1 β Antibody, rabbit monoclonal
      References
      Product Information
      FormatPurified
      Presentation100 μL of rabbit monoclonal IgG in 60% storage buffer (50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
      Applications
      ApplicationPlease note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-IL-1 β Antibody, rabbit is validated for use in WB for the detection of IL-1 β.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated recombinant human IL-1 beta.
      HostRabbit
      SpecificityRecognizes recombinant human IL-1 beta.
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
      Gene Symbol
      • IL1B
      • IL1F2
      • IL-1
      • IL-1B
      • catabolin
      • pro-interleukin-1-beta
      • IL1-BETA
      • Catabolin
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01584 # Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
      SIZE: 269 amino acids; 30748 Da
      SUBUNIT: Monomer.
      SUBCELLULAR LOCATION: Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
      DOMAIN: SwissProt: P01584 The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
      SIMILARITY: Belongs to the IL-1 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-IL-1 beta 2471436
      Anti-IL-1 beta (Rabbit monoclonal IgG) - 2143458 2143458
      Anti-IL-1 beta (Rabbit monoclonal IgG) - 2002996 2002996
      Anti-IL-1 beta (Rabbit monoclonal IgG) - 2095319 2095319
      Anti-IL-1 beta (Rabbit monoclonal IgG) - 2276283 2276283
      Anti-IL-1 beta (Rabbit monoclonal IgG) - DAM1467583 DAM1467583
      Anti-IL-1 beta - 2068518 2068518
      Anti-IL-1 beta - DAM1588280 DAM1588280
      Anti-IL-1 beta - DAM1695887 DAM1695887
      Anti-IL-1 beta - DAM1811099 DAM1811099

      References

      Reference overviewPub Med ID
      Biologic basis for interleukin-1 in disease
      Dinarello, C A
      Blood, 87:2095-147 (1996)  1996

      8630372 8630372
      The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme
      Yuan, J, et al
      Cell, 75:641-652 (1993)  1993

      8242740 8242740
      Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs
      March, C J, et al
      Nature, 315:641-647 ()  1985

      2989698 2989698

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies