06-1091 | Anti-IL-13 receptor Antibody, alpha-2 (IL-13RA2)

06-1091
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1091
      DescriptionAnti-IL-13 receptor Antibody, alpha-2 (IL-13RA2)
      Alternate Names
      • interleukin 13 receptor, alpha 2
      • interleukin-13 receptor subunit alpha-2
      • interleukin 13 receptor alpha 2 chain
      • Interleukin-13-binding protein
      • IL-13R subunit alpha-2
      • cancer/testis antigen 19
      • IL-13 receptor subunit alpha-2
      • interleukin 13 binding protein
      • IL-13R-alpha-2
      • CD213a2 antigen
      Background InformationInterleukin-13 receptor subunit alpha-2 (IL-13RA2) is one receptor of Interleukin-13 which is a key moderator of asthma and allergic inflammation. IL-13 and its receptors have been shown to play a part in alcohol-mediated activation of pro-fibrotic pathways. IL-13 has a suppressive effect on macrophage activation but cannot activate T cells.
      References
      Product Information
      FormatAffinity Purified
      Control
      • HeLa cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-IL-13 receptor Antibody, alpha-2 (IL-13RA2) is an antibody against IL-13 receptor for use in WB, IH(P).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesWestern Blot (SNAP i.d.® Protein Detection System) Analysis: 5 µg/mL from a previous lot detected Interleukin-13 receptor, alpha-2 in 10 µg of HeLa cell lysate.

      Immunohistochemistry (paraffin) Analysis: A 1:500 dilution from a previous lot was used to detect Interleukin-13 receptor, alpha-2 in colorectal carcinoma and normal human kidney/medulla tissue sections.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Interleukin-13 receptor, alpha-2 at the cytoplasmic domain.
      EpitopeCytoplasmic Domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes Interleukin-13 receptor, alpha-2 at the cytoplasmic domain.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq].
      Gene Symbol
      • IL13RA2
      • CD213a2
      • IL-13R
      • CT19
      • IL13BP
      • CD213A2
      • IL-13RA2
      • IL13R
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

      DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

      The box 1 motif is required for JAK interaction and/or activation.

      SEQUENCE SIMILARITIES: Belongs to the type I cytokine receptor family. Type 5 subfamily.

      Contains 1 fibronectin type-III domain.
      Molecular Weight~44 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HeLa cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected Interleukin-13 receptor, alpha-2 in 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-IL-13 receptor, alpha-2 (IL-13RA2) - 2397159 2397159
      Anti-IL-13 receptor, alpha-2 (IL-13RA2) - 2291731 2291731
      Anti-IL-13 receptor, alpha-2 (IL-13RA2) - NRG1831975 NRG1831975
      Anti-IL-13 receptor, alpha-2 (IL-13RA2) -2848117 2848117
      Anti-IL-13 receptor, alpha-2 -2514191 2514191
      Anti-IL-13 receptor, alpha-2 -2694467 2694467

      References

      Reference overviewPub Med ID
      Chitinase 3-like-1 and its receptors in Hermansky-Pudlak syndrome-associated lung disease.
      Zhou, Y; He, CH; Herzog, EL; Peng, X; Lee, CM; Nguyen, TH; Gulati, M; Gochuico, BR; Gahl, WA; Slade, ML; Lee, CG; Elias, JA
      The Journal of clinical investigation  125  3178-92  2015

      Show Abstract
      26121745 26121745