04-463 | Anti-IL-15 Antibody, rabbit monoclonal

04-463
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-463
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-IL-15 Antibody, rabbit monoclonal
      References
      Product Information
      FormatPurified
      Presentation100 μL of rabbit monoclonal IgG in 60% storage buffer (50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
      Applications
      ApplicationPlease note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-IL-15 Antibody, rabbit is validated for use in WB for the detection of IL-15.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated recombinant human IL-15.
      HostRabbit
      SpecificityRecognizes recombinant human IL-15.
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported.
      Gene Symbol
      • IL15
      • MGC9721
      • IL-15
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P40933 # Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.
      SIZE: 162 amino acids; 18086 Da
      SUBCELLULAR LOCATION: Isoform IL15-S48AA: Secreted. & Isoform IL15-S21AA: Cytoplasm. Nucleus. Note=IL15-S21AA is not secreted, but rather is stored intracellularly, appearing in the nucleus and cytoplasmic components.
      TISSUE SPECIFICITY: Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15- S21AA is preferentially expressed in tissues such as testis and thymus.
      SIMILARITY: SwissProt: P40933 ## Belongs to the IL-15 family.
      Molecular Weight15kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-IL-15 (Rabbit monoclonal IgG) - 2387389 2387389
      Anti-IL-15 (Rabbit monoclonal IgG) - 2398119 2398119
      Anti-IL-15 (Rabbit monoclonal IgG) - 2432480 2432480
      Anti-IL-15 - DAM1687956 DAM1687956
      Anti-IL-15 -2545743 2545743
      Anti-IL-15, Rabbit Monoclonal - 0611046364 0611046364

      References

      Reference overviewPub Med ID
      Differential intracellular trafficking, secretion and endosomal localization of two IL-15 isoforms
      Gaggero, A, et al
      Eur J Immunol, 29:1265-74 (1999)  1999

      10229094 10229094
      Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.
      Giri, J G, et al.
      EMBO J., 13: 2822-30 (1994)  1994

      Show Abstract
      8026467 8026467

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies