04-464 | Anti-IL-17 Antibody, rabbit monoclonal

04-464
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWBRbPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-464
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-IL-17 Antibody, rabbit monoclonal
      References
      Product Information
      FormatPurified
      Presentation100 μL of rabbit monoclonal IgG in 60% storage buffer (50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
      Applications
      ApplicationPlease note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-IL-17 Antibody, Rabbit detects level of IL-17 & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated recombinant human IL-17.
      HostRabbit
      SpecificityRecognizes recombinant human IL-17.
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
      Gene Symbol
      • IL17A
      • IL-17A
      • CTLA-8
      • IL17
      • IL-17
      • CTLA8
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q16552 # Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts.
      SIZE: 155 amino acids; 17504 Da
      SUBUNIT: Homodimer.
      SUBCELLULAR LOCATION: Secreted.
      TISSUE SPECIFICITY: Restricted to activated memory T-cells.
      PTM: Found both in glycosylated and nonglycosylated forms.
      SIMILARITY: SwissProt: Q16552 ## Belongs to the IL-17 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-IL-17 (Rabbit monoclonal IgG) - 1963067 1963067
      Anti-IL-17 (Rabbit monoclonal IgG) - 2271141 2271141
      Anti-IL-17 - DAM1518375 DAM1518375
      Anti-IL-17 - DAM1718119 DAM1718119
      Anti-IL-17 - NG1817602 NG1817602
      Anti-IL-17 - NG1923448 NG1923448
      Anti-IL-17, Rabbit Monoclonal - 0611046367 0611046367

      References

      Reference overviewPub Med ID
      Interleukin-17.
      Fossiez, F, et al.
      Int. Rev. Immunol., 16: 541-51 (1998)  1998

      Show Abstract
      9646176 9646176
      Human IL-17: a novel cytokine derived from T cells
      Yao, Z, et al
      J Immunol, 155:5483-6 (1995)  1995

      7499828 7499828

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies