06-1073 | Anti-IL-20R alpha Antibody

06-1073
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, Chp, MkWB, IHC, FCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1073
      DescriptionAnti-IL-20R alpha Antibody
      Alternate Names
      • Cytokine receptor class-II member 8
      • Cytokine receptor family 2 member 8
      • class II cytokine receptor ZCYTOR7
      • interleukin 20 receptor, alpha
      • interleukin-20 receptor I
      Background InformationIL-20R alpha (interleukin-20 receptor alpha) is a subunit of several receptor dimers. The IL-20R alpha and beta dimer is a receptor for IL-20, IL-19 and IL-24. The IL-20R alpha and IL-10R beta dimer is a receptor for IL-26. IL-20 is a cytokine involved in the regulation of proliferation and differentiation of keratinocytes during inflammation, particularly in the skin. IL-20R is widely expressed with highest levels in the skin, testis and brain. This protin is found to be upregulated in psoriasis and other skin inflammatory disorders.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Human testis tissue lysate
      PresentationPurified rabbit polyclonal in PBS with 0.05% sodium azide.
      Applications
      ApplicationAnti-IL-20R alpha Antibody detects level of IL-20R alpha & has been published & validated for use in WB, IH, FC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Flow Cytometry
      Application NotesImmunohistochemistry Analysis: A 1:100 dilution from a previous lot detected IL-20R alpha in mouse epididymal duct.

      Flow Cytometry Analysis: 5 µg from a previous lot detected IL-20R alpha in HeLa cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human IL-20R alpha near the cytoplasmic domain.
      EpitopeCytoplasmic Domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes IL-20R alpha.
      Species Reactivity
      • Human
      • Mouse
      • Chimpanzee
      • Monkey
      Species Reactivity NoteProven to react with human and mouse.
      Predicted to react with chimpanzee and monkey based on 100% sequence homology.
      Mouse (68% sequence homology). Rat (62% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a receptor for interleukin 20 (IL20), a cytokine that may be involved in epidermal function. The receptor of IL20 is a heterodimeric receptor complex consisting of this protein and interleukin 20 receptor beta (IL20B). This gene and IL20B are highly expressed in skin. The expression of both genes is found to be upregulated in Psoriasis. [provided by RefSeq]
      Gene Symbol
      • CRF2-8
      • IL-20R-alpha
      • IL-20R1
      • ZCYTOR7
      • ZcytoR7
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.

      SUBUNIT STRUCTURE: Heterodimer with IL20RB and heterodimer with IL10RB.

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein By similarity.

      TISSUE SPECIFICITY: Widely expressed with highest levels in skin and testis and high levels in brain. Highly expressed in psoriatic skin.

      SEQUENCE SIMILARITIES: Belongs to the type II cytokine receptor family.

      Contains 2 fibronectin type-III domains.
      Molecular Weight~62 kDa was observed.
      2 isoforms produced by alternative splicing may be detected: isoform 1 (~62 kDa) and isoform 2 (~50 kDa).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human testis tissue lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected IL-20R alpha in 10 µg of human testis tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications