06-1077-I | Anti-IL-22RA-1 Antibody

06-1077-I
100 μg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MFC, IH(P), WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1077-I
      Replaces06-1077
      DescriptionAnti-IL-22RA-1 Antibody
      Alternate Names
      • Interleukin-22 receptor subunit alpha-1
      • CRF2-9
      • Cytokine receptor class-II member 9
      • Cytokine receptor family 2 member 9
      • IL-22 receptor subunit alpha-1
      • IL-22R-alpha-1
      • IL-22RA1
      • ZcytoR11
      Background InformationInterleukin-22 receptor subunit alpha-1 (UniProt Q8N6P7; also known as CRF2-9, Cytokine receptor class-II member 9, Cytokine receptor family 2 member 9, IL-22 receptor subunit alpha-1, IL-22R-alpha-1, IL-22RA1, ZcytoR11) is encoded by the IL22RA1 (also known as IL22R) gene (Gene ID 58985) in human. IL-22RA-1 is a member of the type II cytokine receptor family that complexes with IL-10RB and mediates JAK/STAT signaling. IL22 binding to heterodimer is greater than binding to IL22RA1 alone. IL-22RA-1 is expressed in colon, liver, lung, pancreas and kidney, however, no expression is observed in immune cells, such as monocytes, T-cells, and NK-cells. It is also detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions. Higher expression has been observed in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationThis rabbit polyclonal Anti-IL-22RA-1 Antibody, Cat. No. 06-1077-I is validated for use in Flow Cytometry, Immunohistochemistry (Paraffin), and Western Blotting for the detection of Interleukin-22 receptor subunit alpha-1.
      Key Applications
      • Flow Cytometry
      • Immunohistochemistry (Paraffin)
      • Western Blotting
      Application NotesFlow Cytometry Analysis: 1 µg from a representative lot detected IL-22RA-1 immunoreactivity among one million 4% paraformaldehyde-fixed, 0.2% Triton X-100-permeabilized SW480 human colon cancer cells.

      Immunohistochemistry Analysis: A 1:250-1,000 dilution from a representative lot detected IL-22RA-1 in human tonsil and prostate tissue sections.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to a sequence within the C-terminal region of human IL-22RA-1 cytoplasmic domain.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis polyclonal antibody targets a C-terminal sequence within the cytoplasmic domain of human IL-22 receptor subunit alpha-1.
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteHuman, Mouse.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • IL22RA1
      • IL22R
      Purification MethodAffinity purified.
      UniProt Number
      Molecular Weight~63 kDa observed. 61.54 kDa (signal peptide a.a. 1-15 removed) calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse spleen tissue lysate.

      Western Blotting Analysis: 2 µg/mL of this antibody detected IL-22RA-1 in 10 µg of mouse spleen tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications