06-1082-I | Anti-IL-27A Antibody

06-1082-I
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHC, FCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1082-I
      Replaces06-1082
      DescriptionAnti-IL-27A Antibody
      Alternate Names
      • Interleukin-27 subunit alpha
      • IL-27 subunit alpha
      • IL-27-A
      • IL27-A
      • Interleukin-30
      • p28
      • IL-27A
      Background InformationInterleukin 27 (IL-27) is a heterodimeric cytokine belonging to the IL-12 family that is composed of two subunits: Epstein-Barr virus (EBV)-induced gene 3 (EBI3) (also known as IL-27B) and IL27-p28 (known as IL-27A). IL-27 has pro- and anti-inflammatory properties, that can regulate T helper cell development, suppress T-cell proliferation, stimulate cytotoxic T cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. IL-27 is secreted by antigen-presenting cells and plays an important function in regulating the activity of B and T lymphocytes. IL-27 suppresses the expression of GATA3, the inhibitor of TH1 cell development. In addition to suppressing cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T cells. Another important role of IL-27 is its anti-tumor activity as well as its anti-angiogenic activity with activation of production of anti-angiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. In vein endothelial cells, it induces IRF1/interferon regulatory factor 1 and increases the expression of MHC class II transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II. IL-27 also demonstrates antiviral activity with inhibitory properties on HIV-1 replication.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-IL-27A Antibody is an antibody against IL-27A for use in Western Blotting, Immunohistochemistry and Flow Cytometry.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Flow Cytometry
      Application NotesImmunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected IL-27A in human placenta and human tonsil tissue.
      Flow Cytometry Analysis: 0.5 µg of this antibody from a representative lot detected IL-27A in 1X10E6 staph enterotoxin B treated human peripheral blood mononuclear cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human IL-27A.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • IL27
      • IL27A
      • IL30
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~27 kDa observed. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human placenta tissue lysate.

      Western Blotting Analysis: 2.0 µg/mL of this antibody detected IL-27A in 10 µg of human placenta tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Catalogue Number Description  
      06-1082 Anti-Interleukin 27 (IL-27) Antibody Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies