04-367 | Anti-IRAK3 Antibody, rabbit monoclonal

100 µL  
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      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MIP, WBRbPurifiedMonoclonal Antibody
      Catalogue Number04-367
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-IRAK3 Antibody, rabbit monoclonal
      Alternate Names
      • IRAKM
      Product Information
      Presentation100 µL of rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 0.09 M NaCl, 0.006% sodium azide and 0.03% BSA and 40% glycerol.
      ApplicationPlease note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect IRAK3 using this Anti-IRAK3 Antibody, rabbit validated for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Application NotesImmunoblot Analysis: A 1:2,000 dilution of the lot detected IRAK3 CT in lysates from A431 cells.

      A 1:50 dilution of this antibody immunoprecipitated IRAK3 CT using protein G:agarose beads.
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide corresponding to residues in the C-term of human IRAK-3
      SpecificityRecognizes the C-term domain of IRAK3.
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • IRAK3
      • IRAKM
      • IRAK-3
      • ASRT5
      • IRAK-M
      Purification MethodSerum
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9Y616 # Inhibits dissociation of IRAK1 and IRAK4 from the Toll- like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity).
      COFACTOR: Magnesium.
      SIZE: 596 amino acids; 67753 Da
      TISSUE SPECIFICITY: Expressed predominantly in peripheral blood lymphocytes.
      DISEASE: SwissProt: Q9Y616 # Defects in IRAK3 are associated with susceptibility to asthma-related traits type 5 (ASRT5) [MIM:611064]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.
      SIMILARITY: SwissProt: Q9Y616 ## Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. & Contains 1 death domain. & Contains 1 protein kinase domain.
      Molecular Weight68 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-IRAK3 CT - 2537439 2537439


      Reference overviewPub Med ID
      Tumor cells deactivate human monocytes by up-regulating IL-1 receptor associated kinase-M expression via CD44 and TLR4.
      del Fresno, Carlos, et al.
      J. Immunol., 174: 3032-40 (2005)  2005

      Show Abstract
      15728517 15728517
      Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients.
      Escoll, Pedro, et al.
      Biochem. Biophys. Res. Commun., 311: 465-72 (2003)  2003

      Show Abstract
      14592437 14592437
      Identification and characterization of murine IRAK-M
      Rosati, Olaf and Martin, Michael U
      Biochem Biophys Res Commun, 293:1472-7 (2002)  2002

      12054681 12054681

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      Life Science Research > Antibodies and Assays > Primary Antibodies