04-369 | Anti-IRR α subunit Antibody, rabbit monoclonal

04-369
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RIP, WBRbPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-369
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-IRR α subunit Antibody, rabbit monoclonal
      Alternate Names
      • INSRR
      References
      Product Information
      FormatPurified
      Presentation100 µL of rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 0.09 M NaCl, 0.006% sodium azide and 0.03% BSA and 40% glycerol.
      Applications
      ApplicationAnti-IRR α subunit Antibody, rabbit detects level of IRR α subunit & has been published & validated for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Application NotesImmunoblot Analysis: A 1:2,000 dilution of the lot detected IRR alpha subunit in lysates from PC12, MCF-7, HeLa and SHSY5Y cells.


      Immunohistochemistry:
      A 1:50-1:100 dilution of this antibody was used in immunohistochemical analysis of Paraffin-embedded human kidney tissue using the anti-IRR alpha subunit antibody.

      Biological Information
      ImmunogenKLH-conjugated synthetic peptide near the N-terminus of human IRR alpha subunit.
      HostRabbit
      SpecificityRecognizes the IRR alpha subunit
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • INSRR
      • IRR
      Purification MethodSerum
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P14616 # This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity. It phosphorylates the insulin receptor substrates IRS-1 and IRS-2.
      SIZE: 1297 amino acids; 143720 Da
      SUBUNIT: Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      SIMILARITY: SwissProt: P14616 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. & Contains 4 fibronectin type-III domains. & Contains 1 protein kinase domain.
      Molecular Weight80/144 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-IRR alpha subunit, rabbit monoclonal - 0611045587 0611045587

      References

      Reference overviewPub Med ID
      Expression of the insulin receptor-related receptor is induced by the preovulatory surge of luteinizing hormone in thecal-interstitial cells of the rat ovary
      Dissen, Gregory A, et al
      Endocrinology, 147:155-65 (2006)  2006

      16195402 16195402
      Comparative analysis of the signaling capabilities of the insulin receptor-related receptor
      Klammt, Jurgen, et al
      Biochem Biophys Res Commun, 327:557-64 (2005)  2005

      15629149 15629149
      Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas
      Weber, Axel, et al
      Clin Cancer Res, 9:5683-92 (2003)  2003

      14654552 14654552