05-699 | Anti-IRS1 Antibody, clone 1M92-7

05-699
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, RICC, IHC, IPMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-699
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-IRS1 Antibody, clone 1M92-7
      References
      Product Information
      FormatPurified
      Presentation20mM NaPO4, pH 7.4, 125mM NaCl, 0.07% sodium azide before the addition of glycerol to 30%
      Applications
      ApplicationAnti-IRS1 Antibody, clone 1M92-7 is an antibody against IRS1 for use in IC, IH & IP.
      Key Applications
      • Immunocytochemistry
      • Immunohistochemistry
      • Immunoprecipitation
      Application NotesNot recommended for WB.
      Biological Information
      ImmunogenFull length recombinant rat IRS-1 protein produced in baculovirus without tags
      Clone1M92-7
      HostMouse
      SpecificityIRS1
      IsotypeIgG1κ
      Species Reactivity
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • IRS1
      • IRS-1
      • HIRS-1
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P35568 # May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
      SIZE: 1242 amino acids; 131591 Da
      SUBUNIT: Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR via the PTB domain. Binds to phosphatidylinositol 3-kinase p85 subunit via the phosphorylated YXXM motifs. Binds ROCK1. Binds to UBTF and PIK3CA in nuclear extracts (By similarity). Interacts with SOCS7.
      PTM: Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor (By similarity). & Phosphorylation of Tyr-896 is required for GRB2-binding (By similarity).DISEASE:SwissProt: P35568 # Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].
      SIMILARITY: SwissProt: P35568 ## Contains 1 IRS-type PTB domain. & Contains 1 PH domain.
      Molecular Weight~165 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoprecipitating IRS-1 from 500mg of 3T3/A31 RIPA lysate
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-IRS1, clone 1M92-7 (mouse monoclonal IgG1κ) - 2395706 2395706
      Anti-IRS1, clone 1M92-7 (mouse monoclonal IgG1k) - 05-699 05-699
      Anti-IRS1, clone 1M92-7 - 2448054 2448054
      Anti-IRS1, clone 1M92-7 - 24348 24348
      Anti-IRS1, clone 1M92-7 - 28902 28902
      Anti-IRS1, clone 1M92-7 - DAM1411329 DAM1411329

      References

      Reference overviewApplicationPub Med ID
      Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease.
      McFarland, KN; Das, S; Sun, TT; Leyfer, D; Xia, E; Sangrey, GR; Kuhn, A; Luthi-Carter, R; Clark, TW; Sadri-Vakili, G; Cha, JH
      PloS one  7  e41423  2012

      Show Abstract
      Western Blotting22848491 22848491
      Effect of insulin levels on the phosphorylation of specific amino acid residues in IRS-1: implications for burn-induced insulin resistance.
      Lu, XM; Hamrahi, VF; Tompkins, RG; Fischman, AJ
      International journal of molecular medicine  24  531-8  2009

      Show Abstract
      19724894 19724894
      Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development.
      Ciraolo, E; Iezzi, M; Marone, R; Marengo, S; Curcio, C; Costa, C; Azzolino, O; Gonella, C; Rubinetto, C; Wu, H; Dastrù, W; Martin, EL; Silengo, L; Altruda, F; Turco, E; Lanzetti, L; Musiani, P; Rückle, T; Rommel, C; Backer, JM; Forni, G; Wymann, MP; Hirsch, E
      Science signaling  1  ra3  2008

      Show Abstract
      18780892 18780892
      The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action.
      White, M F
      Recent Prog. Horm. Res., 53: 119-38 (1998)  1998

      9769706 9769706

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies