05-1066-25UG | Anti-Insulin Antibody, clone E11D7 (mouse monoclonal)

25 μg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RELISA, IH(P)MPurifiedMonoclonal Antibody
      Catalogue Number05-1066-25UG
      DescriptionAnti-Insulin Antibody, clone E11D7 (mouse monoclonal)
      Background InformationInsulin is a polypeptide hormone that regulates carbohydrate metabolism. Apart from being the primary agent in carbohydrate homeostasis, it has effects on fat metabolism.
      Product Information
      PresentationPurified mouse monolconal IgG1 in 0.1M Tris-Glycine (pH7.4), 150mM NaCl with 0.05%NaN3
      ApplicationAnti-Insulin Antibody, clone E11D7 detects level of Insulin & has been published & validated for use in ELISA, IH(P).
      Key Applications
      • ELISA
      • Immunohistochemistry (Paraffin)
      Application NotesELISA (Direct) Analysis:
      Insulin-coated plate was incubated with Anti-Insulin, clone E11D7 in 2-fold serial dilutions diluted in PBST from 5 μg/mL to 0.01 μg/mL.
      Biological Information
      ImmunogenHuman recombinant Insulin
      ConcentrationPlease refer to lot specific datasheet.
      SpecificityRecognizes insulin
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteHuman tested. Not tested with other species, but expected to react with Mouse and Rat based on sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryAfter removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
      Gene Symbol
      • INS
      • proinsulin
      • insulin
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01308 # Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
      SIZE: 110 amino acids; 11981 Da
      SUBUNIT: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
      DISEASE:SwissProt: P01308 # Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].
      SIMILARITY: SwissProt: P01308 ## Belongs to the insulin family.
      Molecular Weight6 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceImmunohistochemistry Analysis:
      20 μg/mL of this antibody detected insulin in β cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8ºC from date of receipt.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information