06-1095 | Anti-Interferon Beta Antibody

06-1095
200 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, BWB, NEUT, IH(P)RbSerumPolyclonal Antibody
      Description
      Catalogue Number06-1095
      DescriptionAnti-Interferon Beta Antibody
      Alternate Names
      • interferon, beta 1, fibroblast
      • interferon beta
      • Fibroblast interferon
      • IFN-beta
      Background InformationInterferon beta is a type I IFN regulatory cytokine belonging to a conserved family of secreted proteins that have demonstrated growth-inhibitory, immunomodulatory and antiviral properties. Due to these properties, the type I IFNs have been of considerable interest and use in various clinical functions. Studies have shown Interferon beta to be a potent immunomodulator and tumor growth suppressor through the down-regulation of MGMT. Also, there has been great interest in this cytokine as a possible approach to gene therapy for patients infected with AIDS.
      References
      Product Information
      FormatSerum
      Control
      • Recombinant human Interferon Beta
      PresentationRabbit polyclonal containing serum with 0.05% sodium azide.
      Applications
      ApplicationDetect Interferon Beta using this Anti-Interferon Beta Antibody validated for use in WB, NEUT, IH(P).
      Key Applications
      • Western Blotting
      • Neutralizing
      • Immunohistochemistry (Paraffin)
      Application NotesNeutralizing Activity Assay Analysis: One unit of neutralization activity is defined as the amount of antibody serum required to inactivate one unit of Interferon Beta activity in a viral resistant assay, i.e., VSV virus and MDBK cell line (Rubinstein S. Familletti, P.C. and Pestka S. Journal of Virology, 1981, 37:755-758). Neutralization activity is measured by the inhibition of VSV infection of MDBK cells in the presence and absence of the neutralization antibody (ability of the antibody to block interferon's protection of MDBK from VSV infection). This antibody has a neutralization activity of 6.0 x 10^5 units/mL. (Note: Interferon Beta response is species specific)

      Immunohistochemistry (Paraffin) Analysis: A 1:500 dilution from a previous lot detected Interferon Beta in benign prostate tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the internal domain of human Interferon beta.
      EpitopeInternal Domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes Interferon beta.

      Bioactivity
      1.2 x 10^5 Units @ 6.0 x 10^5 Neutralization Units/mL
      Species Reactivity
      • Human
      • Bovine
      Species Reactivity NoteDemonstrated to react with human and bovine.
      Rhesus monkey and chimpanzee (91% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • IFNB1
      • IFB
      • IFF
      • IFNB
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: Has antiviral, antibacterial and anticancer activities.

      SUBUNIT STRUCTURE: Monomer.

      SUBCELLULAR LOCATION: Secreted.

      PHARMACEUTICAL USE: Available under the names Avonex (Biogen), Betaseron (Berlex) and Rebif (Serono). Used in the treatment of multiple sclerosis (MS). Betaseron is a slightly modified form of IFNB1 with two residue substitutions.

      SEQUENCE SIMILARITIES: Belongs to the alpha/beta interferon family.
      Molecular Weight~ 18 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in recombinant human Interferon beta.

      Western Blot Analysis: A 1:500 dilution of this antibody detected 10 µg of recombinant human Interferon Beta.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies