06-1074 | Anti-Interleukin 21 (IL-21) Antibody

06-1074
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, Mk, ChpFC, IH(P), WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1074
      DescriptionAnti-Interleukin 21 (IL-21) Antibody
      Alternate Names
      • Za11
      • IL-21
      • IL21
      • Interleukin-21
      Background InformationInterleukin 21 (IL-21) is a cytokine that has immunoregulatory activity on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells. IL-21 induces cell division/proliferation in its target cells and is expressed in activated human CD4+ T cells. IL-21 may promote the transition between innate and adaptive immunity and may play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. IL-21 expression is up-regulated in Th2 and Th17 subsets of T helper cells, as well as follicular T cells. Furthermore IL-21 is expressed in NK T cells regulating the function of these cells. IL-21 is also produced by Hodgkin's lymphoma (HL) cancer cells and may explain a great deal of the behavior of classical Hodgkin's lymphoma including clusters of other immune cells gathered around HL cells in cultures.
      References
      Product Information
      FormatAffinity Purified
      Control
      • K562 cell lysate
      PresentationPurified rabbit polyclonal in PBS with 0.06% sodium azide.
      Applications
      ApplicationAnti-Interleukin 21 (IL-21) Antibody is an antibody against Interleukin 21 (IL-21) for use in FC, IH(P) & WB.
      Key Applications
      • Flow Cytometry
      • Immunohistochemistry (Paraffin)
      • Western Blotting
      Application NotesFlow Cytometry Analysis: 5 µg from a previous lot detected IL-21 in human PBMC's.

      Immunohistochemistry Analysis: A 1:100 dilution from a previous lot detected IL-21 in mouse spleen tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the C-terminus of human IL-21.
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes the C-terminus of IL-21.
      Species Reactivity
      • Human
      • Mouse
      • Monkey
      • Chimpanzee
      Species Reactivity NoteDemonstrated to react with human and mouse.
      Predicted to react with monkey and chimpanzee based on 100% sequence homology.
      Cow, canine, equine, and porcine (93% sequence homology). Rat (86% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • IL21
      • IL-21
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells By similarity. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.

      SUBCELLULAR LOCATION: Secreted

      TISSUE SPECIFICTY: Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.

      SEQUENCE SIMILARITIES: Belongs to the IL-15/IL-21 family.
      Molecular WeightA molecular weight of 18 kDa was observed; however, UniProtKB/Swiss-Prot entry Q9HBE4 (IL21_HUMAN) describes 2 isoforms produced by alternative splicing: isoform 1 at 18 kDa, isoform 2 at 17 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in K562 cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected IL-21 on 10 µg of K562 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Interleukin 21 (IL-21) - 2383587 2383587
      Anti-Interleukin 21 (IL-21) - 2437350 2437350
      Anti-Interleukin 21 (IL-21) - 2462831 2462831
      Anti-Interleukin 21 (IL-21) - 2197274 2197274
      Anti-Interleukin 21 (IL-21) - 2492781 2492781
      Anti-Interleukin 21 (IL-21) - NG1840502 NG1840502
      Anti-Interleukin 21 (IL-21) - NG1873213 NG1873213
      Anti-Interleukin 21 (IL-21) - NRG1700057 NRG1700057
      Anti-Interleukin 21 (IL-21) -2757881 2757881
      Anti-Interleukin 21 (IL-21) -2761614 2761614

      Brochure

      Title
      Product Selection Guide - Antibodies, small molecule inhibitors, kits, assays and proteins for signaling research.

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies